Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 1

Review Article

Overcome Cancer Cell Drug Resistance Using Natural Products

Table 1

Natural products that can overcome drug resistance without mechanistic information.

Compound nameDoseCell modelChemodrugIDS1Reference

Single compound
 4′-Methylether-scutellarein20 μg/mLJAR/VP16Etoposide5.0[61]
 Dauricine2.5 μg/mLK562/ADMDoxorubicin5.0[62]
 Dihydroartemisinin0.3 μMA549/CDDPCisplatin12.3[63]
 Ginsenoside Rh240 μMMCF/ADMDoxorubicin31.1[64]
 Isorhynchophylline1.5–3 μg/mLA549/DDPVarious7.2–24.3[6567]
 Ligustrazine2.6–10 μg/mLK562/ADMDoxorubicin6.0–178[68, 69]
 Matrine50 μg/mLK562/ADMDoxorubicin2.2[70]
 Peiminine20 μg/mLSGC7901/VCRVarious6–27[71]
 Schizandrol A25 μMHL60/ADRDaunorubicin8[72]
 Tanshinone II A0.2 μg/mLMCF/ADMDoxorubicin2.5[73]
Single herb extract
Eleutherococcus senticosus200 μg/mLK562/ADRDaunomycin4.2[74]
Andrographis paniculata2.4 μg/mLCHT8/5FUVarious2.1–2.2[75]
 Indigowoad root31 μg/mLBEL7404/ADMDoxorubicin4.8[76]
Formula extract
 Danggui Buxue recipe300 μg/mLSGC7901/ADRDoxorubicin2.8[77]
 Fufang Jinzi recipe5 μg/mLK562/VCRVincristine3.6[78]

IDS, increase in drug sensitivity (-fold).
IDS = IC50 in control group/IC50 in experimental group.