Review Article
Overcome Cancer Cell Drug Resistance Using Natural Products
Table 1
Natural products that can overcome drug resistance without mechanistic information.
| Compound name | Dose | Cell model | Chemodrug | IDS1 | Reference |
| Single compound | | | | | | 4′-Methylether-scutellarein | 20 μg/mL | JAR/VP16 | Etoposide | 5.0 | [61] | Dauricine | 2.5 μg/mL | K562/ADM | Doxorubicin | 5.0 | [62] | Dihydroartemisinin | 0.3 μM | A549/CDDP | Cisplatin | 12.3 | [63] | Ginsenoside Rh2 | 40 μM | MCF/ADM | Doxorubicin | 31.1 | [64] | Isorhynchophylline | 1.5–3 μg/mL | A549/DDP | Various | 7.2–24.3 | [65–67] | Ligustrazine | 2.6–10 μg/mL | K562/ADM | Doxorubicin | 6.0–178 | [68, 69] | Matrine | 50 μg/mL | K562/ADM | Doxorubicin | 2.2 | [70] | Peiminine | 20 μg/mL | SGC7901/VCR | Various | 6–27 | [71] | Schizandrol A | 25 μM | HL60/ADR | Daunorubicin | 8 | [72] | Tanshinone II A | 0.2 μg/mL | MCF/ADM | Doxorubicin | 2.5 | [73] | Single herb extract | | | | | | Eleutherococcus senticosus | 200 μg/mL | K562/ADR | Daunomycin | 4.2 | [74] | Andrographis paniculata | 2.4 μg/mL | CHT8/5FU | Various | 2.1–2.2 | [75] | Indigowoad root | 31 μg/mL | BEL7404/ADM | Doxorubicin | 4.8 | [76] | Formula extract | | | | | | Danggui Buxue recipe | 300 μg/mL | SGC7901/ADR | Doxorubicin | 2.8 | [77] | Fufang Jinzi recipe | 5 μg/mL | K562/VCR | Vincristine | 3.6 | [78] |
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IDS, increase in drug sensitivity (-fold). IDS = IC50 in control group/IC50 in experimental group.
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