PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid -Induced Cognitive Deficits through Modulation of Neuroinflammation

Figure 2

Effects of PMC-12 on Aβ expression and microglia and astrocyte activations in -injected mouse brain. Photomicrographs showed immunohistochemically (a) Aβ (4G8), (b) Iba-1 (a sensitive marker of microglial activation), and (c) GFAP (a sensitive marker of astrocyte activation) stained brains at 3 weeks after injection. Either PMC-12 (100 and 200 mg/kg) or an equal volume of distilled water (Veh) was administered once a day for 3 weeks. Aβ, Iba-1, and GFAP immunoreactivities were increased in the CA1 regions of the hippocampus with vehicle treatment in mice but were attenuated by treatment with PMC-12. The results shown are representative of those obtained from four independent experiments. The scale bar is 20 μm.

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