PMC-12, a Prescription of Traditional Korean Medicine, Improves Amyloid -Induced Cognitive Deficits through Modulation of Neuroinflammation

Figure 3

Effects of PMC-12 on inflammatory mediators in -injected mouse brain. The brain tissues of -injected mice were analyzed for iNOS, COX-2, IL-1β, IL-6, TLR-2, and TLR-4 mRNA levels by real-time PCR. These gene expression levels were normalized to GAPDH. Either PMC-12 (100 and 500 mg/kg) or an equal volume of distilled water (Veh) was administered orally 3 weeks after injection. PMC-12 significantly decreased iNOS, COX-2, IL-1β, IL-6, TLR-2, and TLR-4 mRNA levels in Aβ-injected brain. ^* and ^** versus vehicle (Veh). Data shown are the mean ± SEM of values from four separate experiments.