UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model

<div>Effect of UP3005 composition on GAG releasing. Cartilage explants were incubated for 24 h in DMEM with 1% heat-inactivated FBS. Each set of data represents the means ± SD (−): control cultured medium without IL-1α; IL-1α: cultured medium treated with IL-1α (5 ng/mL); Diclofenac-300: cultured medium treated with IL-1α plus 300 μg/mL of Diclofenac; UP3005-50/100/200: cultured medium treated with IL-1α plus UP3005 at doses of 50/100 or 200 μg/mL.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model

Figure 1 | UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model 