UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model
Table 2
Percent changes of pain sensitivity by composition UP3005 in MIA-induced OA rat model.
Group/dose
Week
0
1
2
3
4
5
6
G1 = normal
Mean
174.53
172.53
174.67
175.40
171.40
166.07
163.60
SD
29.51
6.53
13.90
23.95
39.09
19.86
9.32
%
100.00
98.85
100.08
100.50
98.20
95.15
93.74
G2 = vehicle
Mean
173.23
158.07
151.90
160.07
143.10
121.03
122.07
SD
18.04
15.08
42.97
16.12
23.00
12.77
15.17
%
100.00
91.24
87.69
92.40
82.61
69.87
70.46
G3 = Diclofenac (10 mg/kg)
Mean
173.20
146.37
155.67
162.90
150.90
146.23
144.23
SD
15.61
27.86
23.85
28.90
19.62
22.73
27.57
%
100.00
84.51
89.88
94.05
87.12
84.43
83.28
G4 = UP3005 (500 mg/kg)
Mean
173.33
168.13
178.87
174.37
166.90
170.00
148.93
SD
17.44
22.68
57.83
26.48
27.17
21.13
26.12
%
100.00
97.00
103.19
100.60
96.29
98.08
85.92
values versus vehicle G2
G1
0.9311
0.0226
0.1535
0.2446
0.1907
0.0041
0.0000
G3
0.9965
0.2626
0.8120
0.7905
0.4255
0.0085
0.0428
G4
0.9901
0.2600
0.2532
0.1655
0.0491
0.0000
0.0135
Paw withdrawal thresholds as a result of constant pressure applied perpendicular to the hind paw as a measure of pain sensitivity were taken once a week using Randall-Salitto Anesthesiometer. Applied pressures were translated into grams by the Anesthesiometer. = 10 rats/group.
