Aortic Remodelling Is Improved by 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats

Figure 3

Influence of THSG on PAI-1 expression. (a) Rat PAI-1 mRNA detected using quantitative RT-PCR in aortas of WKY rats, SHRs, and SHRs treated with THSG (). Densitometric analysis was performed based on 3 separate experiments. Data are expressed as the mean ± SEM. versus WKY; versus SHRs. (b) Aortal sections were incubated with primary antibodies against PAI-1, followed by FITC-labelled rabbit IgG secondary antibodies. DAPI fluorescence staining was used as control. Immunofluorescence staining was performed using a fluorescence microscope. Scale bar = 500 μm.

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