Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 789027, 10 pages
http://dx.doi.org/10.1155/2015/789027
Research Article

Aortic Remodelling Is Improved by 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats

Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received 11 September 2015; Accepted 15 October 2015

Academic Editor: Kuzhuvelil B. Harikumar

Copyright © 2015 Ju Duan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. A. Suwanabol, K. C. Kent, and B. Liu, “TGF-β and restenosis revisited: a Smad link,” Journal of Surgical Research, vol. 167, no. 2, pp. 287–297, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Saltis and A. Bobik, “Regulation by protein kinase C of transforming growth factor-β1 action on the proliferation of vascular smooth muscle cells from spontaneously hypertensive rats,” Clinical and Experimental Pharmacology and Physiology, vol. 23, no. 6-7, pp. 573–575, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Tahira, N. Fukuda, M. Endo et al., “Transforming growth factor-β expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension,” Hypertension Research, vol. 25, no. 6, pp. 911–918, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Zacchigna, C. Vecchione, A. Notte et al., “Emilin1 links TGF-β maturation to blood pressure homeostasis,” Cell, vol. 124, no. 5, pp. 929–942, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Ishimura, J. K. Ng, M. Taira, S. G. Young, and S.-I. Osada, “Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor β signaling,” Development, vol. 133, no. 19, pp. 3919–3928, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C.-Z. Song, T. E. Siok, and T. D. Gelehrter, “Smad4/DPC4 and Smad3 mediate transforming growth factor-β (TGF-β) signaling through direct binding to a novel TGF-β-responsive element in the human plasminogen activator inhibitor-1 promoter,” The Journal of Biological Chemistry, vol. 273, no. 45, pp. 29287–29290, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. Stroschein, W. Wang, and K. Luo, “Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor β-induced Smad-dependent transcriptional activation,” Journal of Biological Chemistry, vol. 274, no. 14, pp. 9431–9441, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. Q.-L. Liu, J.-H. Xiao, R. Ma, Y. Ban, and J.-L. Wang, “Effect of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells,” Journal of Asian Natural Products Research, vol. 9, no. 8, pp. 689–697, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. X.-L. Xu, Y.-J. Huang, Y.-Q. Wang, X.-F. Chen, and W. Zhang, “2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells by regulating the cell cycle,” Clinical and Experimental Pharmacology and Physiology, vol. 38, no. 5, pp. 307–313, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Wang, J. Gu, P.-F. Wu et al., “Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation,” Free Radical Biology and Medicine, vol. 47, no. 3, pp. 229–240, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Yoshiyuki, O. Hiromichi, and A. Shigeru, “Effects of stilbenes on arachidonate metabolism in leukocytes,” Biochimica et Biophysica Acta—Lipids and Lipid Metabolism, vol. 834, no. 2, pp. 275–278, 1985. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Zhang, X.-L. Xu, Y.-Q. Wang, C.-H. Wang, and W.-Z. Zhu, “Effects of 2,3,4′,5-Tetrahydroxystilbene 2-O-β-D-glucoside on vascular endothelial dysfunction in atherogenic-diet rats,” Planta Medica, vol. 75, no. 11, pp. 1209–1214, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. X.-L. Xu, D.-Y. Ling, Q.-Y. Zhu, W.-J. Fan, and W. Zhang, “The effect of 2,3,4′,5-tetrahydroxystilbene-2-O-β-d glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms,” European Journal of Pharmacology, vol. 698, no. 1–3, pp. 370–378, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. X.-P. Yang, T.-Y. Liu, X.-Y. Qin, and L.-C. Yu, “Potential protection of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside against staurosporine-induced toxicity on cultured rat hippocampus neurons,” Neuroscience Letters, vol. 576, pp. 79–83, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. M.-J. Chang, J.-H. Xiao, Y. Wang, Y.-L. Yan, J. Yang, and J.-L. Wang, “2, 3, 5, 4′-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice,” PLoS ONE, vol. 7, no. 12, Article ID e50291, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Li, F. Cai, Y. Yang et al., “Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway,” European Journal of Pharmacology, vol. 649, no. 1–3, pp. 382–389, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Y.-Y. Zhao, L. Zhang, Y.-L. Feng et al., “Pharmacokinetics of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside in rat using ultra-performance LC-quadrupole TOF-MS,” Journal of Separation Science, vol. 36, no. 5, pp. 863–871, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Zhang, W.-F. Ma, J. Li et al., “Influence of processing on pharmacokinetic of typical constituents in radix polygoni multiflori after oral administration by LC-ESI-MS/MS,” Journal of Ethnopharmacology, vol. 148, no. 1, pp. 246–253, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Sun, Y. Sun, H. Li, and W. Sun, “Influence of main component of Heshouwu such as emodin, rhein and toluylene glycoside on hepatic cells and hepatoma carcinoma cells,” Xian Dai Zhong Xi Yi Jie He Za Zhi, vol. 19, pp. 1315–1317, 2010 (Chinese). View at Google Scholar
  20. X.-Q. Hu, J. Zhuo, Y.-L. Li, J.-S. Wang, and L. Wang, “Effects of stilbene glucoside from Polygonum Multiflorum Thunb. on hepatic enzymes and serum albumin of rats,” Liao Ning Zhong Yi Za Zhi, vol. 38, pp. 988–990, 2011 (Chinese). View at Google Scholar
  21. X. Han, S. Ling, W. Gan, L. Sun, J. Duan, and J.-W. Xu, “2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation,” Atherosclerosis, vol. 225, no. 1, pp. 76–82, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. P.-G. Li, L. Sun, X. Han, S. Ling, W.-T. Gan, and J.-W. Xu, “Quercetin induces rapid eNOS phosphorylation and vasodilation by an akt-independent and PKA-dependent mechanism,” Pharmacology, vol. 89, no. 3-4, pp. 220–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Dennler, S. Itoh, D. Vivien, P. ten Dijke, S. Huet, and J.-M. Gauthier, “Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitortype 1 gene,” The EMBO Journal, vol. 17, no. 11, pp. 3091–3100, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Hamet, V. Hadrava, U. Kruppa, and J. Tremblay, “Transforming growth factor β1 expression and effect in aortic smooth muscle cells from spontaneously hypertensive rats,” Hypertension, vol. 17, no. 6, pp. 896–901, 1990. View at Google Scholar · View at Scopus
  25. J. Behbahani, S. J. Thandapilly, X. L. Louis et al., “Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, pp. 365–371, 2005. View at Google Scholar
  26. T. Furumoto, S. Fujii, K. Nishihara et al., “Maladaptive arterial remodeling with systemic hypertension associated with increased concentrations in blood of plasminogen activator inhibitor type-1 (PAI-1),” American Journal of Cardiology, vol. 93, no. 8, pp. 997–1001, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Naito, T. Tsujino, D. Kawasaki et al., “Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats,” Journal of Hypertension, vol. 21, no. 6, pp. 1107–1115, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. P. G. Anderson, S. P. Bishop, and S. B. Digerness, “Vascular remodeling and improvement of coronary reserve after hydralazine treatment in spontaneously hypertensive rats,” Circulation Research, vol. 64, no. 6, pp. 1127–1136, 1989. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Lemne, T. Jogestrand, and U. de Faire, “Carotid intima-media thickness and plaque in borderline hypertension,” Stroke, vol. 26, no. 1, pp. 34–39, 1995. View at Publisher · View at Google Scholar · View at Scopus
  30. X.-L. Xu, Y.-J. Huang, X.-F. Chen, D.-Y. Lin, and W. Zhang, “2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits proliferation of vascular smooth muscle cells: involvement of NO/cGMP/PKG pathway,” Phytotherapy Research, vol. 26, no. 7, pp. 1068–1074, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Shen, C.-H. Wang, Y.-Q. Wang, F. Li, and W. Zhang, “Effects of 2, 3, 4′, 5-tetrahydroxystilbene-2-O-β-D-glucoside on content of nitric oxide synthase and expression of nitric oxide synthase in artery vessels of experimental atherosclerotic rats,” Zhongguo Zhong Yao Za Zhi, vol. 33, no. 8, pp. 919–923, 2008 (Chinese). View at Google Scholar · View at Scopus
  32. J. Behbahani, S. J. Thandapilly, X. L. Louis et al., “Resveratrol and small artery compliance and remodeling in the spontaneously hypertensive rat,” American Journal of Hypertension, vol. 23, no. 12, pp. 1273–1278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. S. R. Bhatt, M. F. Lokhandwala, and A. A. Banday, “Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats,” European Journal of Pharmacology, vol. 667, no. 1–3, pp. 258–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Mizutani, K. Ikeda, and Y. Yamori, “Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats,” Biochemical and Biophysical Research Communications, vol. 274, no. 1, pp. 61–67, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. J. W. E. Rush, J. Quadrilatero, A. S. Levy, and R. J. Ford, “Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats,” Experimental Biology and Medicine, vol. 232, no. 6, pp. 814–822, 2007. View at Google Scholar · View at Scopus
  36. A. Nishihara, J.-I. Hanai, N. Okamoto et al., “Role of p300, a transcriptional coactivator, in signalling of TGF-β,” Genes to Cells, vol. 3, no. 9, pp. 613–623, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Inoue, Y. Itoh, K. Abe et al., “Smad3 is acetylated by p300/CBP to regulate its transactivation activity,” Oncogene, vol. 26, no. 4, pp. 500–508, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Simonsson, M. Kanduri, E. Grönroos, C.-H. Heldin, and J. Ericsson, “The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation,” Journal of Biological Chemistry, vol. 281, no. 52, pp. 39870–39880, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. A. W. Tu and K. Luo, “Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor β response,” Journal of Biological Chemistry, vol. 282, no. 29, pp. 21187–21196, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. O. A. Paniagua, M. B. Bryant, and J. A. Panza, “Role of endothelial nitric oxide in shear stress-induced vasodilation of human microvasculature: diminished activity in hypertensive and hypercholesterolemic patients,” Circulation, vol. 103, no. 13, pp. 1752–1758, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. H.-J. Hsieh, C.-A. Liu, B. Huang, A. H. Tseng, and D. L. Wang, “Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications,” Journal of Biomedical Science, vol. 21, article 3, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. K. Magyar, L. Deres, K. Eros et al., “A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats,” Biochimica et Biophysica Acta, vol. 1842, no. 7, pp. 935–944, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. L. Deres, E. Bartha, A. Palfi et al., “PARP-inhibitor treatment prevents hypertension induced cardiac remodeling by favorable modulation of heat shock proteins, Akt-1/GSK-3β and several PKC isoforms,” PLoS ONE, vol. 9, no. 7, Article ID e102148, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. M. J. Cipolla, N. Bishop, R. S. Vinke, and J. A. Godfrey, “PPARγ activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats,” Stroke, vol. 41, no. 6, pp. 1266–1270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. N. Koibuchi, Y. Hasegawa, T. Katayama et al., “DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure,” Cardiovascular Diabetology, vol. 13, article 157, 2014. View at Publisher · View at Google Scholar
  46. S.-W. Jang, S.-H. Ihm, E.-H. Choo et al., “Imatinib mesylate attenuates myocardial remodeling through inhibition of platelet-derived growth factor and transforming growth factor activation in a rat model of hypertension,” Hypertension, vol. 63, no. 6, pp. 1228–1234, 2014. View at Publisher · View at Google Scholar · View at Scopus