Bioactive Polyphenols from the Methanol Extract of Cnicus arvensis (L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice
Table 4
Effects of Cnicus arvensis extract on formalin induced paw licking test in mice.
Groups
First phase
Late phase
Duration of licking
% inhibition
Duration of licking
% inhibition
Control 1% tween 80 in water
38.17 ± 1.27
—
46.5 ± 0.99
—
Positive control 10 mg/kg bd. wt.
12.00 ± 0.70*
68.56
13.17 ± 0.48*
71.69
Plant extract 150 mg/kg bd. wt.
11.50 ± 2.42*
69.87
12.50 ± 2.72*
73.12
Plant extract 300 mg/kg bd. wt.
9.33 ± 1.35*
75.55
5.83 ± 1.35*
87.46
bd. wt. = body weight; values are mean ± SEM; ; *.