Research Article

Bioactive Polyphenols from the Methanol Extract of Cnicus arvensis (L.) Roth Demonstrated Antinociceptive and Central Nervous System Depressant Activities in Mice

Table 4

Effects of Cnicus arvensis extract on formalin induced paw licking test in mice.

GroupsFirst phaseLate phase
Duration of licking% inhibitionDuration of licking% inhibition

Control
1% tween 80 in water
38.17 ± 1.2746.5 ± 0.99
Positive control
10 mg/kg bd. wt.
12.00 ± 0.70*68.5613.17 ± 0.48*71.69
Plant extract
150 mg/kg bd. wt.
11.50 ± 2.42*69.8712.50 ± 2.72*73.12
Plant extract
300 mg/kg bd. wt.
9.33 ± 1.35*75.555.83 ± 1.35*87.46

bd. wt. = body weight; values are mean ± SEM; ; *.