Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes

Table 1

Enzymatic kinetic parameters for berberine, coptisine, and palmatine metabolites in HLMs.

Metabolites	(M)	(Area/min/mg pro)	(Area/min/mg/pro/M)
B1	32.24	4.174	0.13
B2	32.83	3.071	0.10
C	36.35	1.808	0.05
P	87.47	2.447	0.03

Note: B1, metabolite 1 of berberine; B2, metabolite 2 of berberine; C, metabolite of coptisine; P, metabolite of palmatine.