Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis

Figure 5

TNF-α plasma levels in experimental arthritis. A significant increase in plasma levels of TNF-α was found in CIA-control mice. Levels of TNF-α were significantly reduced in CIA-EA mice in comparison to CIA-control animals. There was no significant change in either CIA-EA-SCH58261 mice or CIA-SCH58261 mice in comparison to CIA-control animals. However, the levels of TNF-α in CIA-EA-SCH58261 and CIA-SCH58261 mice were significantly greater than in CIA-EA mice. Values (ng/L) are means ± SEM of 10 animals for each group. versus Sham-control. ^Δ versus CIA-control. ^# versus CIA-EA.