Research Article

Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis

Figure 3

Primo vessels were involved in gastric cancer metastasis. (a) A free primo vessel (black arrow) with a thread-like and semitransparent appearance between tumors. (b) Under the LZ12 microscope, a tiny metastatic tumor (black arrow) was observed in the primo vessel. (c) Magnification of (b); more microtumors or gastric cancer cells (yellow arrows) were detected. (d) HE staining for the metastatic tumor mediated by primo vessels. (e) Magnification of framed area of (d) (Bar: 100 μm). (f) Transversal section of the primo vessel embedded was stained by H&E (Bar: 50 μm). No vascular vessels or lymphatic vessels were observed in either metastatic tumors or primo vessels. (g) Primo vessels involved in gastric cancer metastasis showed rod shape nuclei in a linear arrangement (white arrows) and positively expressed phalloidin.
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