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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 832314, 5 pages
Research Article

Bidens pilosa Formulation Improves Blood Homeostasis and β-Cell Function in Men: A Pilot Study

1Chun-Yueh Biomedical Technology Co., Ltd., Taipei 116, Taiwan
2Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan
3Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
4Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
5Department of Cancer Biology and Medicine, China Medical University, Taichung 404, Taiwan
6Department of Chinese Medicine, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan
7Department of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 402, Taiwan

Received 18 August 2014; Accepted 18 September 2014

Academic Editor: Wen-Chin Yang

Copyright © 2015 Bun-Yueh Lai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


B. pilosa has long been purported to have antidiabetes activity, but despite the advancement in phytochemistry and animal models of diabetes, no human clinical trials have been conducted to date. Here, we evaluated the effect of a B. pilosa formulation on fasting blood glucose (FBG), fasting serum insulin, and glycosylated hemoglobin A1c in diabetic subjects. The B. pilosa formulation reduced the level of FBG and in diabetics but increased fasting serum insulin in healthy subjects. Moreover, combination of B. pilosa formulation with antidiabetic drugs had better glycemic control in diabetics. The homeostatic model assessment (HOMA) data suggested that the antidiabetic activity of this formulation was via improvement of β-cell function. We also tested the safety of the B. pilosa formulation in healthy subjects and observed no obvious side effects. We conclude that B. pilosa has potential as an antidiabetes treatment.