Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells

Figure 7

The scheme represents the effect of gigantol on human lung cancer cells. The present study reveals that gigantol has an ability to reduce CSCs markers including CD133 and ALDH1A1 in the cancer cells by suppressing the activation of protein kinase B (Akt) signal which in turn decreased the cellular levels of pluripotency and self-renewal factors Oct4 and Nanog.