Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 840742, 8 pages
http://dx.doi.org/10.1155/2015/840742
Review Article

Efficacy of Compound Kushen Injection in Relieving Cancer-Related Pain: A Systematic Review and Meta-Analysis

1China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China
2Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China

Received 14 May 2015; Accepted 11 June 2015

Academic Editor: Cheryl Hawk

Copyright © 2015 Yu-ming Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. McMillan, M. Tittle, S. Hagan, and J. Laughlin, “Management of pain and pain-related symptoms in hospitalized veterans with cancer,” Cancer Nursing, vol. 23, no. 5, pp. 327–336, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Carr, L. Goudas, D. Lawrence et al., “Management of cancer symptoms: pain, depression, and fatigue,” Evidence Report/Technology Assessment (Summary), no. 61, pp. 1–5, 2002. View at Google Scholar · View at Scopus
  3. N. Wells, “Pain intensity and pain interference in hospitalized patients with cancer,” Oncology Nursing Forum, vol. 27, no. 6, pp. 985–991, 2000. View at Google Scholar · View at Scopus
  4. E. Ernst and B. R. Cassileth, “The prevalence of complementary/alternative medicine in cancer: a systematic review,” Cancer, vol. 83, no. 4, pp. 777–782, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. Richardson, T. Sanders, J. L. Palmer, A. Greisinger, and S. E. Singletary, “Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology,” Journal of Clinical Oncology, vol. 18, no. 13, pp. 2505–2514, 2000. View at Google Scholar · View at Scopus
  6. J. Tian, W.-H. Wang, H.-M. Cao, and Z.-M. Wang, “Determination of matrine, sophoridine and oxymatrine in compound Kushen injection by HPLC,” Zhongguo Zhongyao Zazhi, vol. 32, no. 3, pp. 222–224, 2007. View at Google Scholar · View at Scopus
  7. Z. Zhao, H. Fan, T. Higgins et al., “Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways,” Cancer Letters, vol. 355, no. 2, pp. 232–241, 2014. View at Publisher · View at Google Scholar
  8. C. Liang, G. Yanwei, W. Zhiwei et al., “Clinical observation of compound Kushen injection combined with TACE in treatment of liver cancer,” Clinical Chinese Journal of Information on TCM, vol. 21, no. 6, pp. 98–99, 2014. View at Google Scholar
  9. D. Li, L. Zhuangwei, W. Yiting et al., “Efficacy of compound kushen injection by continuously intravenous infusion combined with TACE in treating middle-and-late stage primary liver cancer,” in Proceedings of the China Cancer Academic Conference 2008 of TCM & National TCM Academic Conference of Famous Doctors, pp. 118–120, Beijing, China, 2008.
  10. D. Li, L. Zhuangwei, W. Yiting et al., “Effect of matrine injections continuous infusion combined TACE treatment 30 cases with advanced liver cancer,” Journal of Practical Traditional Chinese Internal Medicine, vol. 24, no. 11, pp. 22–24, 2010. View at Google Scholar
  11. F. Jianwei, D. Yuan, and H. Wei, “Clinical observation on healing 40 cases advanced stage 14 gastric cancer with composite kushen injection and chemotherapy,” Journal of Emergency in Traditional Chinese Medicine, vol. 20, no. 1, pp. 152–153, 2011. View at Google Scholar
  12. G. Jianlin, L. Hong, and W. Liping, “Clinical observation on healing 63 case advanced stage NSCLC with composite kusheng injection and NP program,” Journal of XinJiang Medical University, vol. 29, no. 9, pp. 1018–1019, 2007. View at Google Scholar
  13. L. Yihang and L. Yinghui, “Clinical observation of gastric cancer treated by chemotherapy combined with Yanshu injection,” Jilin Medical Journal, vol. 31, no. 30, p. 5332, 2011. View at Google Scholar
  14. L. Yanru, “Research on non-small cell lung cancer treating with compound kushen injection and thermotherapy,” Chinese Journal of Modern Drug Application, vol. 7, no. 6, pp. 71–72, 2013. View at Google Scholar
  15. S. Jing and Y. Liping, “Clinical observation on late stage lung cancer treating with chemotherapy and compound kushen injection,” Traditional Chinese medicine in Inner Mongolia, vol. 11, pp. 13–14, 2012. View at Google Scholar
  16. S. Xinwen, “Addition of compound Kushen injection to vinorelbine plus cisplatin for patients with nonsmall cell lung cancer clinical observation,” Evaluation and Analysis of Drug-Use in Hospitals of China, vol. 12, no. 7, pp. 645–648, 2012. View at Google Scholar
  17. W. Huijuan, Z. Hongzhi, and L. Tao, “Clinical observation of late nonsmall-cell lung cancer treated by chemotherapy combined with yanshu injection,” Evaluation and Analysis of Drug-Use in Hospitals of China, vol. 6, no. 1, pp. 43–45, 2006. View at Google Scholar
  18. W. Shuo, L. Hongsheng, Z. Xinwen et al., “A randomized and multicenter clinical trial of compound matrine injection combined with hepatic artery interventional therapy in treatment of primary liver cancer,” Chinese Journal of Clinical Oncology and Rehabilitation, vol. 21, no. 3, pp. 331–335, 2014. View at Google Scholar
  19. X. Jinxiu, Z. Shiye, W. Airong et al., “Clinical observation of compound Kushen injection combined with FOLFOX regimen in treatment of advanced gastric cancer,” Chinese Archives of Traditional Chinese Medicine, vol. 31, no. 8, pp. 1812–1815, 2013. View at Google Scholar
  20. X. Xiaodong, Z. Zhendong, L. Dawei et al., “Clinical observation on improving the quality of life on late stage of colorectal carcinoma with compound matrine injections,” in Proceedings of the 10th National Combine Traditional Chinese and Western Medicine Tumor Academic Conference, pp. 294–296, Shenyang, China, 2006.
  21. Y. Jie, C. Xiang, Z. Xiaobing et al., “Clinical observation of colorectal cancer treating with compound kushen injection and chemotherapy,” Medical Recapitula, vol. 13, no. 23, pp. 1872–1874, 2007. View at Google Scholar
  22. Y. Zhengang and W. Bingzhe, “Efficacy of large dose of compound matrine injection combined chemotherapy for non-small-cell lung cancer,” Evaluation and Analysis of Drug-Use in Hospitals of China, vol. 12, no. 2, pp. 149–152, 2012. View at Google Scholar
  23. Z. Jincao and S. Peng, “Clinical study on com pound Sophora flavescens Ait com bined with chemotherapy for colorectal—cancer,” Journal of Clinical Medicine in Practice, vol. 16, no. 11, pp. 101–103, 2012. View at Google Scholar
  24. M. S. Walid, S. N. Donahue, D. M. Darmohray et al., “The fifth vital sign—what does it mean?” Pain Practice, vol. 8, no. 6, pp. 417–422, 2008. View at Google Scholar
  25. P. Sloan and R. Melzack, “Long-term patterns of morphine dosage and pain intensity among cancer patients,” The Hospice Journal, vol. 14, no. 2, pp. 35–47, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Cassileth, C. Trevisan, and J. Gubili, “Complementary therapies for cancer pain,” Current Pain and Headache Reports, vol. 11, no. 4, pp. 265–269, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Wang, R. L. You, W. J. Qin et al., “Anti-tumor activities of active ingredients in Compound Kushen Injection,” Acta Pharmacologica Sinica, vol. 36, no. 6, pp. 676–679, 2015. View at Publisher · View at Google Scholar
  28. B. Yanju, L. Yang, B. Hua et al., “A systematic review and meta-analysis on the use of traditional Chinese medicine compound kushen injection for bone cancer pain,” Supportive Care in Cancer, vol. 22, no. 3, pp. 825–836, 2014. View at Publisher · View at Google Scholar
  29. Q. Sun, W. Ma, Y. Gao, W. Zheng, B. Zhang, and Y. Peng, “Meta-analysis: therapeutic effect of transcatheter arterial chemoembolization combined with compound kushen injection in hepatocellular carcinoma,” African Journal of Traditional, Complementary, and Alternative Medicines, vol. 9, no. 2, pp. 178–188, 2012. View at Google Scholar · View at Scopus
  30. K. F. Schulz, D. G. Altman, D. Moher, and The CONSORT Group, “CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials,” PLoS Medicine, vol. 7, no. 3, Article ID e1000251, 2010. View at Publisher · View at Google Scholar · View at Scopus