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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 853846, 9 pages
http://dx.doi.org/10.1155/2015/853846
Research Article

Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus acutissima Cortex

1Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan
2Kampo Formulations Development Center, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan

Received 29 November 2014; Accepted 6 January 2015

Academic Editor: Alfredo Vannacci

Copyright © 2015 Junichi Koseki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material contains 4 figures and 2 tables.

Figure S1: shows that there is no cytotoxic effect of BK and pentagalloyl glucose in hamster primary sebocytes.

Figure S2 presents the bioconversion of exogenous dihydrotestosterone to 5α-androstane-3,17-diol by rat liver microsomal enzymes.

Figure S3 gives the chemical structure of 1,2,3,4,6-penta-O-galloyl glucose (pentagalloyl glucose).

Figure S4 shows the reduction of generation of reactive oxygen species by BK.

Table S1 presents the methods of LC-MS/MS: ion parameters of test compounds.

Table S2 presents the LC-MS/MS Methods: HPLC conditions.

  1. Supplementary Material