Review on the Applications and Molecular Mechanisms of Xihuang Pill in Tumor Treatment

Table 1

Clinical applications of XH on tumor therapies.

Diseases	Research method	Combined with/single use	Antitumor effect	Symptoms remission	Ref.
Non-Hodgkin lymphoma	RCT (60 cases)	CHOP regimen	Enhance OS for 3 years	Relieve cancer-related symptoms; Enhance KPS	[6]
Breast cancer	(60 cases); RCT (84 cases); (40 cases); (120 cases)	CEF regimen; TEC regimen; Letrozole; Zoledronic acid	Enhance OS for 2 years; Enhance RR; Enhance FPS; Treat bone metastasis	Relieve cancer-related symptoms; Relieve endocrinotherapy-induced side-effects; Relieve CIBP; Enhance KPS; Regulate immunity	[14–17]
Primary liver cancer	RCT (80 cases); Clinical observation (23 cases); Clinical observation (28 cases)	TAC (cisplatin); Single use; Single use	Enhance RR; Enhance OS for 1 year and 2 years	Enhance KPS; Relieve cancer-related symptoms	[18–20]
Gastric cancer	RCT (80 cases); Clinical observation (48 cases); Case report (2 cases)	DCF regimen; Single use; Single use	Enhance RR	Relive chemotherapy-induced side-effects; Regulate immunity	[21]
Esophageal cancer	RCT (18 cases)	Platinum and fluorouracil based regimens	Could not enhance the effects of chemotherapies	Improve the live quality; Relieve cancer and chemotherapy-induced symptoms	[22]
Brain glioma	Case report (1 case)	TCM decoctions	Prolong the survival time to 3 years without undergoing resection; Improve the live quality		[23]
Oral mucositis	RCT (60 cases)	Chinese patent medicine	Treat radiation-induced oral mucositis		[24]
Phlebitis	Case report (1 case)	Single use	Treat chemotherapy-induced phlebitis		[25]

The cases number includes the total quantity in the randomized controlled trial (RCT).
Unpublished observations.