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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 860463, 11 pages
http://dx.doi.org/10.1155/2015/860463
Research Article

Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study

1Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
2Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
3Department of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
4Department of Health Care Studies, Daemen College, Amherst, NY 14226, USA
5Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
6Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA

Received 22 July 2015; Accepted 20 September 2015

Academic Editor: Morry Silberstein

Copyright © 2015 Jiliang Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Mahadeva and K.-L. Goh, “Epidemiology of functional dyspepsia: a global perspective,” World Journal of Gastroenterology, vol. 12, no. 17, pp. 2661–2666, 2006. View at Google Scholar · View at Scopus
  2. B. Geeraerts and J. Tack, “Functional dyspepsia: past, present, and future,” Journal of Gastroenterology, vol. 43, no. 4, pp. 251–255, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Camilleri and C. Di Lorenzo, “Brain-gut axis: from basic understanding to treatment of IBS and related disorders,” Journal of Pediatric Gastroenterology and Nutrition, vol. 54, no. 4, pp. 446–453, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. E. A. Mayer, “Gut feelings: the emerging biology of gut-brain communication,” Nature Reviews Neuroscience, vol. 12, no. 8, pp. 453–466, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Camilleri and V. Stanghellini, “Current management strategies and emerging treatments for functional dyspepsia,” Nature Reviews Gastroenterology and Hepatology, vol. 10, no. 3, pp. 187–194, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Lan, F. Zeng, G. J. Liu et al., “Acupuncture for functional dyspepsia,” Cochrane Database of Systematic Reviews, vol. 10, Article ID CD008487, 2014. View at Publisher · View at Google Scholar
  7. Y.-C. Park, W. Kang, S.-M. Choi, and C.-G. Son, “Evaluation of manual acupuncture at classical and nondefined points for treatment of functional dyspepsia: a randomized-controlled trial,” Journal of Alternative and Complementary Medicine, vol. 15, no. 8, pp. 879–884, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. T. T. Ma, S. Y. Yu, Y. Li et al., “Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia,” Alimentary Pharmacology and Therapeutics, vol. 35, no. 5, pp. 552–561, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Zeng, W.-Z. Song, X.-G. Liu et al., “Brain areas involved in acupuncture treatment on functional dyspepsia patients: a PET-CT study,” Neuroscience Letters, vol. 456, no. 1, pp. 6–10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Zeng, W. Qin, T. Ma et al., “Influence of acupuncture treatment on cerebral activity in functional dyspepsia patients and its relationship with efficacy,” The American Journal of Gastroenterology, vol. 107, no. 8, pp. 1236–1247, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. M. D. Fox and M. Greicius, “Clinical applications of resting state functional connectivity,” Frontiers in Systems Neuroscience, vol. 4, article 19, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. D. Fox and M. E. Raichle, “Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging,” Nature Reviews Neuroscience, vol. 8, no. 9, pp. 700–711, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Jin, Q. Zhao, K. Zhou et al., “Acupuncture for functional dyspepsia: a single blinded, randomized, controlled trial,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 904926, 9 pages, 2015. View at Publisher · View at Google Scholar
  14. D. A. Drossman, “The functional gastrointestinal disorders and the Rome III process,” Gastroenterology, vol. 130, no. 5, pp. 1377–1390, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. WHO Regional Office for the Western Pacific, WHO Standard Acupuncture Point Locations in the Western Pacific Region, World Health Organization, Manila, Philippines, 2008.
  16. K. Zhou, J. Fang, X. Wang et al., “Characterization of De Qi with electroacupuncture at acupoints with different properties,” Journal of Alternative and Complementary Medicine, vol. 17, no. 11, pp. 1007–1013, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Jenkinson, P. Bannister, M. Brady, and S. Smith, “Improved optimization for the robust and accurate linear registration and motion correction of brain images,” NeuroImage, vol. 17, no. 2, pp. 825–841, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. S. M. Smith, M. Jenkinson, M. W. Woolrich et al., “Advances in functional and structural MR image analysis and implementation as FSL,” NeuroImage, vol. 23, no. 1, pp. S208–S219, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. T. D. Satterthwaite, M. A. Elliott, R. T. Gerraty et al., “An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data,” NeuroImage, vol. 64, no. 1, pp. 240–256, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. C.-G. Yan, B. Cheung, C. Kelly et al., “A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics,” NeuroImage, vol. 76, pp. 183–201, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. K. R. A. van Dijk, M. R. Sabuncu, and R. L. Buckner, “The influence of head motion on intrinsic functional connectivity MRI,” NeuroImage, vol. 59, no. 1, pp. 431–438, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Biswal, F. Z. Yetkin, V. M. Haughton, and J. S. Hyde, “Functional connectivity in the motor cortex of resting human brain using echo-planar MRI,” Magnetic Resonance in Medicine, vol. 34, no. 4, pp. 537–541, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Wang, R. L. Buckner, and H. Liu, “Functional specialization in the human brain estimated by intrinsic hemispheric interaction,” The Journal of Neuroscience, vol. 34, no. 37, pp. 12341–12352, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Fang, Z. Jin, Y. Wang et al., “The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation,” Human Brain Mapping, vol. 30, no. 4, pp. 1196–1206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Fang, X. Wang, H. Liu et al., “The limbic-prefrontal network modulated by electroacupuncture at CV4 and CV12,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 515893, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. N. J. Talley, M. Haque, J. W. Wyeth et al., “Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index,” Alimentary Pharmacology & Therapeutics, vol. 13, no. 2, pp. 225–235, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. X.-P. Tian, Y. Li, F.-R. Liang et al., “Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China,” World Journal of Gastroenterology, vol. 15, no. 25, pp. 3173–3177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Li, H. M. Wang, and Y. Shen, “Chinese SF-36 Health Survey: translation, cultural adaptation, validation, and normalization,” Journal of Epidemiology and Community Health, vol. 57, no. 4, pp. 259–263, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. J. T. Biggs, L. T. Wylie, and V. E. Ziegler, “Validity of the zung self rating depression scale,” British Journal of Psychiatry, vol. 132, no. 4, pp. 381–385, 1978. View at Publisher · View at Google Scholar · View at Scopus
  30. X. C. Liu, S. Oda, X. Peng, and K. Asai, “Life events and anxiety in Chinese medical students,” Social Psychiatry and Psychiatric Epidemiology, vol. 32, no. 2, pp. 63–67, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Liu, W. Qin, J. Wang et al., “Identifying neural patterns of functional dyspepsia using multivariate pattern analysis: a resting-state fMRI study,” PLoS ONE, vol. 8, no. 7, Article ID e68205, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. F. A. D. R. Lima, L. E. V. V. D. C. Ferreira, and F. H. D. L. Pace, “Acupuncture effectiveness as a complementary therapy in functional dyspepsia patients,” Arquivos de Gastroenterologia, vol. 50, no. 3, pp. 202–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. X. R. Chang, J. Yan, Y. P. Lin, S. X. Yi, and Y. J. Deng, “Influence of puncturing tsusanli point on the gastrointestinal hormone of the plasma of the patients with functional dyspepsia,” Chinese Journal of Integrated Traditional and Western Medicine on Digestion, vol. 9, pp. 283–284, 2001. View at Google Scholar
  34. D. H. Zhang, To study the influence of Shu-Mu-point combination on plasma GAS and GHR in Functional Dyspepsia patients [M.S. thesis], Chengdu University of Traditional Chinese Medicine, Chengdu, China, 2013.
  35. D. A. Drossman, Y. Ringel, B. A. Vogt et al., “Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome,” Gastroenterology, vol. 124, no. 3, pp. 754–761, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. B. H. Jonsson, K. Uvnäs-Moberg, T. Theorell, and R. Gotthard, “Gastrin, cholecystokinin, and somatostatin in a laboratory experiment of patients with functional dyspepsia,” Psychosomatic Medicine, vol. 60, no. 3, pp. 331–337, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Natale, L. Pasquali, A. Paparelli, and F. Fornai, “Parallel manifestations of neuropathologies in the enteric and central nervous systems,” Neurogastroenterology and Motility, vol. 23, no. 12, pp. 1056–1065, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. R. L. Buckner, “The brain's default network: origins and implications for the study of psychosis,” Dialogues in Clinical Neuroscience, vol. 15, no. 3, pp. 351–358, 2013. View at Google Scholar · View at Scopus