Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Fig 1

Research Article

Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain

Figure 1

Effects of chronic pretreatment with MAK on H/I-induced infarction and neurological deficits. (a) Representative data of triphenyltetrazolium chloride (TTC) staining from the coronal brain sections at 24 h of reoxygenation after H/I in the mice. Scale bar = 1 mm. (b) The infarction volume was determined using an image analysis system. Throughout, the data are represented as means ± S.D.; in each group. compared with the sham-operated control group; , 0.001. (c) Motor coordination and balance at 24 h of reoxygenation after H/I were assessed by the rotarod performance test in the mice. , 0.001 compared with the respective sham-operated groups. compared with the H/I-treated control group. (d) Neurological deficits were assessed using the 18-point neurological scoring system consisting of the neurological scoring index (Table 1) at 24 h of reoxygenation after H/I in the mice. The score for each mouse was summed for all five individual test scores. The maximum neurological score of a normal mouse with no deficit is 18. compared with the respective sham-operated groups. compared with the H/I-treated control group.

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