Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma

Figure 5

Glucarate treatment increased glucarate and suppressed -glucuronidase activity in plasma. Effects of glucarate administration on plasma glucarate concentration (a) and -glucuronidase activity (b). Inhibition of -glucuronidase is likely to be caused by glucaro-1,4-lactone, spontaneously produced from glucarate in an aqueous environment. Data represent mean ± SD (–12). ; ; by Dunnett’s test versus vehicle control.

(a)

(b)