Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma
Glucarate treatment increased glucarate and suppressed -glucuronidase activity in plasma. Effects of glucarate administration on plasma glucarate concentration (a) and -glucuronidase activity (b). Inhibition of -glucuronidase is likely to be caused by glucaro-1,4-lactone, spontaneously produced from glucarate in an aqueous environment. Data represent mean ± SD (–12). ; ; by Dunnett’s test versus vehicle control.
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