Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma
Table 2
Metabolites significantly changed in plasma of tumor-bearing and normal rats in response to RKT treatment.
Compound name
Tumor
Normal
Fold change
value
Fold change
value
Glucarate
1.58
<0.0001
1.31
0.026
Alanine
1.45
<0.0001
0.97
0.66
Lactic acid
1.57
<0.0001
1.05
0.58
Adipic acid
1.30
<0.0001
1.05
0.54
Fructose
1.66
0.0001
0.87
0.074
Aspartic acid
1.22
0.0002
1.01
0.84
Pyruvate + oxalacetic acid
1.31
0.0012
1.10
0.23
Oxalate
1.26
0.0019
1.64
0.23
Tryptophan
1.26
0.0059
0.86
0.14
Arabitol
1.48
0.010
1.47
0.0049
Fumaric acid
1.19
0.017
1.04
0.70
Lysine
1.13
0.017
1.07
0.15
Proline
1.36
0.019
0.96
0.75
Phenylalanine
1.19
0.024
0.99
0.94
N-Acetyl-L-glutamate
0.69
0.025
0.94
0.47
Phosphate
1.16
0.036
1.11
0.085
Glucono-1,4-lactone
1.11
0.037
1.13
0.096
Allantoin
1.14
0.041
1.03
0.58
Lauric acid
0.85
0.042
0.69
<0.0001
Cysteine + cystine
0.83
0.043
0.99
0.91
4-Hydroxyphenylacetic acid
1.22
0.044
1.03
0.79
Glucose
1.16
0.044
1.11
0.083
Urea
1.16
0.048
1.10
0.11
Each value represents the fold induction of the peak intensity in RKT-treated rats () against that of vehicle-treated controls (). values were calculated by unpaired Student’s -test.
