Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.

Table 1

Effect of EESD on hole cross test.

Treatment	Dose (mg/kg)	Number of holes crossed (% of inhibition)
		Pretreatment	30 min	60 min	90 min	120 min
Control	0.1 mL/mouse	19 ± 1.58	17.60 ± 0.75	15.6 ± 0.93	13.4 ± 0.51	12.4 ± 0.51
Diazepam	1	21.2 ± 1.63	5.2 ± 1.16^* (70.45)	3.2 ± 0.37^* (79.49)	2.0 ± 0.45^* (85.07)	2.2 ± 0.74^* (82.26)
EESD	50	18.6 ± 1.69	12.6 ± 1.54^* (28.41)	10.2 ± 1.20^* (34.62)	7.2 ± 1.16^* (46.27)	4.2 ± 0.97^* (66.13)
EESD	100	20.4 ± 1.08	8.80 ± 0.49^* (50.00)	7.8 ± 1.02^* (50.00)	3.6 ± 0.81^* (73.13)	3.2 ± 0.86^* (74.19)
EESD	200	21 ± 0.84	6.0 ± 0.84^* (65.91)	2.0 ± 0.71^* (87.18)	1.6 ± 0.4^* (88.06)	1.2 ± 0.37^* (90.32)

Values are presented as the Mean ± SEM (). EESD = ethanolic extract of Scoparia dulcis; compared with the control group (two-way ANOVA followed by Bonferroni’s test).