Metabolomics Analysis of Seminal Plasma in Infertile Males with Kidney-Yang Deficiency: A Preliminary Study
Table 3
Identified discriminating metabolites in negative mode.
VIP
Retention time (min)
Name
test
Fold change*
1.335
446.0562
0.704
CDP-ethanolamine
0.032
−0.61
1.499
136.0298
0.779
Hypoxanthine
0.012
−0.597
1.557
276.0882
0.788
thymidine glycol
0.008
−0.817
1.441
148.0298
0.844
Citramalic acid
0.017
−0.367
1.364
174.009
0.869
Dehydroascorbic acid
0.027
−0.51
1.404
130.0194
0.879
Glutaconic acid
0.022
−0.6
1.556
315.0483
1.134
5′-Phosphoribosyl-N-formylglycinamide
0.008
−0.68
1.39
192.0193
1.142
Citric acid
0.023
−0.363
1.546
112.009
1.143
Furoic acid
0.009
−0.424
1.344
129.0353
1.171
Pyroglutamic acid
0.03
0.675
1.277
426.0053
1.199
APS/ADP/dGDP
0.043
−0.358
1.698
181.0666
1.2
Tyrosine
0.003
−0.476
1.705
130.0194
1.274
Citraconic acid
0.003
−0.655
1.729
174.009
1.275
Aconitic acid
0.002
−0.643
1.298
489.2731
2.654
PA(21:4)
0.038
0.443
1.397
182.0504
4.672
Homovanillic acid
0.022
−0.482
1.458
129.0352
4.923
Pyrroline hydroxycarboxylic acid
0.016
0.597
1.765
545.2636
9.368
PS(20:4)
0.002
−1.924
1.505
370.2288
11.507
6-Keto-PGF1/TXB2
0.012
−0.415
1.516
531.0692
12.557
CDP-4-dehydro-3,6-dideoxy-D-glucose
0.011
−0.428
2.335
337.2285
13.096
PGA1
0
0.817
1.561
335.2129
13.332
PGA2
0.008
1.066
1.267
256.2323
18.876
Palmitic acid
0.045
0.416
Fold change was calculated as the ratio of the mean metabolite levels between two groups. A positive value of fold change indicates a relatively higher concentration of metabolites while a negative value of fold change indicates a relatively lower concentration in infertile males with KYDS as compared to fertile males.
