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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 913252, 7 pages
http://dx.doi.org/10.1155/2015/913252
Research Article

Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

1School of Traditional Chinese Medicine, Zhejiang Chinese Medicine University, Zhejiang 310053, China
2School of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Heilongjiang 150040, China
3Department of Medicine, The Seventh Hospital of Hangzhou, Mental Health Care of Hangzhou, Zhejiang 310013, China
4School of Medicine, Anhui Medical University, Anhui 230032, China

Received 26 October 2014; Revised 19 January 2015; Accepted 21 January 2015

Academic Editor: Martin Offenbaecher

Copyright © 2015 Lin-lin Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group () and the lorazepam tablet treatment group (). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (), the PSQI (), and wake after sleep onset (WASO; ) scores and improved sleep architecture (–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.