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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 915087, 9 pages
http://dx.doi.org/10.1155/2015/915087
Research Article

The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial

1Department of Gastroenterology, Policlinico di Monza, 20900 Milan, Italy
2Section of Biostatistics, Neurophysiology and Psychiatry, Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
3Research and Development Unit, Indena, 20139 Milan, Italy
4Section of Human Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Azienda di Servizi alla Persona, 27100 Pavia, Italy

Received 9 December 2014; Accepted 23 March 2015

Academic Editor: Xiu-Min Li

Copyright © 2015 Attilio Giacosa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Camilleri, D. Dubois, B. Coulie et al., “Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US upper gastrointestinal study,” Clinical Gastroenterology and Hepatology, vol. 3, no. 6, pp. 543–552, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. R. P. Knill and R. P. Jones, “Geografical differences in the prevalence of dyspepsia,” Scandinavian Journal of Gastroenterology, vol. 26, pp. 17–24, 1991. View at Google Scholar
  3. N. J. Talley, A. R. Zinsmeister, C. D. Schleck, and L. J. Melton III, “Dyspepsia and dyspepsia subgroups: a population-based study,” Gastroenterology, vol. 102, no. 4, pp. 1259–1268, 1992. View at Google Scholar · View at Scopus
  4. G. E. H. Holtmann, H. Goebell, and N. J. Talley, “Dyspepsia in consulters and non-consulters: prevalence, health-care seeking behaviour and risk factors,” European Journal of Gastroenterology and Hepatology, vol. 6, no. 10, pp. 917–924, 1994. View at Publisher · View at Google Scholar · View at Scopus
  5. N. J. Talley, V. Stanghellini, R. C. Heading, K. L. Koch, J. R. Malagelada, and G. N. Tytgat, “Functional gastroduodenal disorders,” Gut, vol. 45, no. 2, pp. 1137–1142, 1999. View at Google Scholar
  6. A. C. Ford, P. Bercik, D. G. Morgan, C. Bolino, M. I. Pintos-Sanchez, and P. Moayyedi, “The Rome III criteria for the diagnosis of functional dyspepsia in secondary care are not superior to previous definitions,” Gastroenterology, vol. 146, no. 4, pp. 932–940, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Mahadeva and K. L. Goh, “Epidemiology of dyspepsia: a global perspective,” World Journal of Gastroenterology, vol. 12, no. 17, pp. 2661–2666, 2006. View at Google Scholar
  8. S. Haag, N. J. Talley, and G. Holtmann, “Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consulters,” Gut, vol. 53, no. 10, pp. 1445–1451, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Stanghellini, F. de Ponti, R. de Giorgio, G. Barbara, C. Tosetti, and R. Corinaldesi, “New developments in the treatment of functional dyspepsia,” Drugs, vol. 63, no. 9, pp. 869–892, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. N. J. Talley, “Dyspepsia: management guidelines for the millennium,” Gut, vol. 50, no. 4, pp. iv72–iv78, 2002. View at Google Scholar · View at Scopus
  11. G. H. Micklefield, Y. Redeker, V. Meister, O. Jung, I. Greving, and B. May, “Effects of ginger on gastroduodenal motility,” International Journal of Clinical Pharmacology and Therapeutics, vol. 37, no. 7, pp. 341–346, 1999. View at Google Scholar · View at Scopus
  12. E. Ernst and M. H. Pittler, “Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials,” British Journal of Anaesthesia, vol. 84, no. 3, pp. 367–371, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Holtmann, B. Adam, S. Haag, W. Collet, E. Grünewald, and T. Windeck, “Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial,” Alimentary Pharmacology & Therapeutics, vol. 18, no. 11-12, pp. 1099–1105, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. N. J. Talley, D. Colin-Jones, K. L. Koch et al., “Functional dyspepsia. A classification with guidelines for diagnosis and management,” Gastroenterology International, vol. 4, pp. 145–160, 1991. View at Google Scholar
  15. N. J. Talley, M. Haque, J. W. Wyeth et al., “Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index,” Alimentary Pharmacology & Therapeutics, vol. 13, no. 2, pp. 225–235, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. World Medical Association, World Medical Association Declaration of Helsinki. Ethical Principles of Medical Research Involving Human Subjects (2013 revision), World Medical Association, Ferney-Voltaire, France, 2004, http://www.wma.net/en/30publications/10policies/b3/.
  17. R. Likert, “A technique for the measurement of attitudes,” Archives of Psychology, vol. 140, pp. 1–55, 1932. View at Google Scholar
  18. J. C. Lohelin, Latent Variable Models: An Introduction to Factor, Path and Structural Equation Analysis, Lawrence Erlbaum Associates, New York, NY, USA, 2004.
  19. P. Mair and J. de Leeuw, “A general framework for multivariate analysis with optimal scaling: the R package aspect,” Journal of Statistical Software, vol. 32, no. 9, pp. 1–23, 2010. View at Google Scholar · View at Scopus
  20. R. P. Bagozzi and Y. Yi, “Specification, evaluation, and interpretation of structural equation models,” Journal of the Academy of Marketing Science, vol. 40, no. 1, pp. 8–34, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Rosseel, “Lavaan: an R package for structural equation modeling,” Journal of Statistical Software, vol. 48, no. 2, pp. 1–36, 2012. View at Google Scholar · View at Scopus
  22. R Development Core Team, R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, Austria, 2013.
  23. G. Dobrilla, M. Comberlato, A. Steele, and P. Vallaperta, “Drug treatment of functional dyspepsia. A meta-analysis of randomized controlled clinical trials,” Journal of Clinical Gastroenterology, vol. 11, no. 2, pp. 169–177, 1989. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Futagami, M. Shimpuku, Y. Yin et al., “Pathophysiology of functional dyspepsia,” Journal of Nippon Medical School, vol. 78, no. 5, pp. 280–285, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. Committee on Herbal Medicinal Products, “Assessment report on Zingiber officinale Roscoe, rhizome,” European Medicines Agency EMA/HMPC/577856/2010, 2011. View at Google Scholar
  26. K.-L. Wu, C. K. Rayner, S.-K. Chuah et al., “Effects of ginger on gastric emptying and motility in healthy humans,” European Journal of Gastroenterology & Hepatology, vol. 20, no. 5, pp. 436–440, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. B. H. Ali, G. Blunden, M. O. Tanira, and A. Nemmar, “Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research,” Food and Chemical Toxicology, vol. 46, no. 2, pp. 409–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Gebhardt and M. Fausel, “Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes,” Toxicology in Vitro, vol. 11, no. 5, pp. 669–672, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Gebhardt, “Inhibition of hepatic cholesterol biosynthesis by artichoke leaf extracts is mainly due to luteolin,” Cell Biology and Toxicology, vol. 13, p. 58, 1997. View at Google Scholar
  30. J. E. Brown and C. A. Rice-Evans, “Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro,” Free Radical Research, vol. 29, no. 3, pp. 247–255, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Pérez-García, T. Adzet, and S. Cañigueral, “Activity of artichoke leaf extract on reactive oxygen species in human leukocytes,” Free Radical Research, vol. 33, no. 5, pp. 661–665, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. A. R. Rechner, A. S. Pannala, and C. A. Rice-Evans, “Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo,” Free Radical Research, vol. 35, no. 2, pp. 195–202, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Ishida, R. Kojima, M. Tsuboi, Y. Tsuda, and M. Ito, “Effects of artichoke leaf extract on acute gastric mucosal injury in rats,” Biological and Pharmaceutical Bulletin, vol. 33, no. 2, pp. 223–229, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Emendörfer, F. Bellato, V. F. Noldin et al., “Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum,” Biological and Pharmaceutical Bulletin, vol. 28, no. 5, pp. 902–904, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Ding, M. Leach, and H. Bradley, “The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review,” Women and Birth, vol. 26, no. 1, pp. e26–e30, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. J. L. Ryan, C. E. Heckler, J. A. Roscoe et al., “Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients,” Supportive Care in Cancer, vol. 20, no. 7, pp. 1479–1489, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Thomson, R. Corbin, and L. Leung, “Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis,” Journal of the American Board of Family Medicine, vol. 27, no. 1, pp. 115–122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Kirchhoff, C. Beckers, G. Kirchhoff, H. Trinczek-Gärtner, O. Petrowicz, and H. Reimann, “Increase in choleresis by means of artichoke extract. Results of a randomized placebo-controlled double blind study,” Phytomedicine, vol. 1, no. 2, pp. 107–115, 1994. View at Publisher · View at Google Scholar
  39. A. Aggarwal and M. Bhatt, “Commonly used gastrointestinal drugs,” Handbook of Clinical Neurology, vol. 120, pp. 633–643, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. S. E. van Roeden, G. Belle-van Meerkerk, S. A. C. van Tuyl, M. A. van De Ree, and A. F. Muller, “Domperidone and the risk of sudden cardiac death,” Nederlands Tijdschrift voor Geneeskunde, vol. 157, no. 46, Article ID A6770, 2013. View at Google Scholar · View at Scopus
  41. L. M. Hondeghem, “Domperidone: limited benefits with significant risk for sudden cardiac death,” Journal of Cardiovascular Pharmacology, vol. 61, no. 3, pp. 218–225, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. V. Michaud and J. Turgeon, “Domperidone and sudden cardiac death: how much longer should we wait?” Journal of Cardiovascular Pharmacology, vol. 61, no. 3, pp. 215–217, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Kanji, A. Stevenson, and B. Hutton, “Sudden cardiac death and ventricular arrhythmias associated with domperidone: evidence supporting health Canada’s warning,” The Canadian Journal of Hospital Pharmacy, vol. 67, no. 4, pp. 311–312, 2014. View at Publisher · View at Google Scholar