The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function

<div>Effect of maoto or kakkonto Kampo formulations on the rate of oseltamivir conversion to the active carboxylate metabolite (OC) in mice with LPS-induced inflammation. Liver microsomal fractions prepared from mice administered three i.p. injections of 3.0 mg/kg LPS were used as a source of carboxylesterase. Data represent the means ± S.D. of 3–5 mice.</div>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function 

Figure 5 | The Inhibitory Effect of Kakkonto, Japanese Traditional (Kampo) Medicine, on Brain Penetration of Oseltamivir Carboxylate in Mice with Reduced Blood-Brain Barrier Function 