Evidence-Based Complementary and Alternative Medicine

Research Article

Assessment of Antifungal Activity of Bakuchiol on Oral-Associated Candida spp.

Table 2

Changes in the specific growth rates (µ) and the viable counts (CFU) of Candida species following bakuchiol exposure. The percentage denotes the inhibition of treated samples compared to the untreated ones.
MicroorganismTreatmentLog10 CFU/mL (%)
C. albicans 
ATCC 14053		Untreated1.73 ± 0.0810.04 ± 0.03
Bakuchiol0.70 ± 0.07 (59.5)7.24 ± 0.08 (27.9)
Amphotericin B0.49 ± 0.10 (71.7)6.64 ± 0.05 (33.9)
C. dubliniensis 
ATCC MYA-2975		Untreated0.98 ± 0.148.32 ± 0.28
Bakuchiol0.45 ± 0.24 (54.1)6.87 ± 0.42 (17.4)
Amphotericin B0.74 ± 0.19 (24.5)7.36 ± 0.09 (11.5)
C. glabrata 
ATCC 90030		Untreated1.80 ± 0.0610.13 ± 0.08
Bakuchiol1.11 ± 0.03 (38.3)8.34 ± 0.07 (17.7)
Amphotericin B1.47 ± 0.13 (18.3)9.20 ± 0.07 (9.2)
C. krusei 
ATCC 14243		Untreated0.82 ± 0.208.63 ± 0.45
Bakuchiol0.73 ± 0.15 (11)5.72 ± 0.35 (33.7)
Amphotericin B0.55 ± 0.12 (32.9)6.32 ± 0.21 (26.8)
C. lusitaniae 
ATCC 64125		Untreated1.09 ± 0.158.95 ± 0.36
Bakuchiol0.42 ± 0.10 (61.5)6.90 ± 0.16 (22.9)
Amphotericin B0.98 ± 0.24 (10.1) 8.69 ± 0.50 (2.9)
C. tropicalis 
ATCC 13803		Untreated1.57 ± 0.149.80 ± 0.43
Bakuchiol1.02 ± 0.18 (35)9.30 ± 0.23 (5.5)
Amphotericin B0.91 ± 0.12 (42)8.63 ± 0.08 (11.9)
Test concentration was prepared at 0.5 × MIC. compared to the untreated samples.