Research Article

Acupuncture for Frequent Migraine: A Randomized, Patient/Assessor Blinded, Controlled Trial with One-Year Follow-Up

Table 6

Primary outcome measurements.

After treatment ()At three months follow-up period I ()One-year follow-up period II ()
RA mean (SD)SA mean (SD)95% CI for difference valueRA mean (SD)SA mean (SD)95% CI for difference valueRA mean (SD)SA mean (SD)95% CI for difference value

Migraine days (number of days with migraine per 4 weeks)5.2 (5.0)10.1 (7.1) (−8.5, −1.3)0.008*5.1 (3.7)9.5 (6.2) (−7.2, −1.4)0.005*11.3 (5.5)12.3 (5.6) (−5.8, 3.7)0.660
Duration (hours/attack)6.0 (3.3)8.0 (4.5) (−4.3, 0.2)0.0738.2 (2.8)8.81 (4.1) (−2.6, 1.3)0.5207.51 (2.6)7.61 (3.5) (−2.6, 2.4)0.930
Highest pain-VAS5.0 (1.8)4.5 (1.9) (−0.2, 1.6)0.3504.8 (1.4)4.66 (2.0) (−0.9, 1.1)0.8005.81 (1.0)4.91 (2.4) (−1.8, 1.2)0.710
Lowest pain-VAS2.3 (1.9)2.5 (1.7) (−1.2, 0.9)0.8202.6 (1.1)2.62 (1.7) (−0.9, 0.7)0.8602.77 (1.5)3.04 (2.1) (−1.0, 2.8)0.310
Average pain-VAS3.0 (1.8)3.2 (1.8) (−1.3, 0.8)0.6503.9 (1.0)3.60 (1.9) (−0.6, 1.7)0.4804.21 (1.1)3.39 (2.1) (−0.8, 2.5)0.290
Severity of pain (six-point Likert scale)2.2 (1.1)2.9 (0.6) (−1.2, −0.3)0.004*2.6 (0.4)2.9 (0.6) (−0.5, 0.0)0.0873.11 (0.5)3.3 (0.7) (−0.7, 0.3)0.420
Responder+19 (73.1%)7 (29.2%)0.020#17 (65.4%)5 (20.8%)0.034#1 (6.3%)0 (0%)

*Statistical significance assessed at 0.05/4 = 0.0125 (Bonferroni correction) for both intention to treat () and per protocol analysis ().
+Responder: participants with 50% or greater reduction in days with migraine.
#Indicates statistical significance assessed at 0.05.