Acupuncture for Frequent Migraine: A Randomized, Patient/Assessor Blinded, Controlled Trial with One-Year Follow-Up
Table 6
Primary outcome measurements.
After treatment ()
At three months follow-up period I ()
One-year follow-up period II ()
RA mean (SD)
SA mean (SD)
95% CI for difference
value
RA mean (SD)
SA mean (SD)
95% CI for difference
value
RA mean (SD)
SA mean (SD)
95% CI for difference
value
Migraine days (number of days with migraine per 4 weeks)
5.2 (5.0)
10.1 (7.1)
(−8.5, −1.3)
0.008*
5.1 (3.7)
9.5 (6.2)
(−7.2, −1.4)
0.005*
11.3 (5.5)
12.3 (5.6)
(−5.8, 3.7)
0.660
Duration (hours/attack)
6.0 (3.3)
8.0 (4.5)
(−4.3, 0.2)
0.073
8.2 (2.8)
8.81 (4.1)
(−2.6, 1.3)
0.520
7.51 (2.6)
7.61 (3.5)
(−2.6, 2.4)
0.930
Highest pain-VAS
5.0 (1.8)
4.5 (1.9)
(−0.2, 1.6)
0.350
4.8 (1.4)
4.66 (2.0)
(−0.9, 1.1)
0.800
5.81 (1.0)
4.91 (2.4)
(−1.8, 1.2)
0.710
Lowest pain-VAS
2.3 (1.9)
2.5 (1.7)
(−1.2, 0.9)
0.820
2.6 (1.1)
2.62 (1.7)
(−0.9, 0.7)
0.860
2.77 (1.5)
3.04 (2.1)
(−1.0, 2.8)
0.310
Average pain-VAS
3.0 (1.8)
3.2 (1.8)
(−1.3, 0.8)
0.650
3.9 (1.0)
3.60 (1.9)
(−0.6, 1.7)
0.480
4.21 (1.1)
3.39 (2.1)
(−0.8, 2.5)
0.290
Severity of pain (six-point Likert scale)
2.2 (1.1)
2.9 (0.6)
(−1.2, −0.3)
0.004*
2.6 (0.4)
2.9 (0.6)
(−0.5, 0.0)
0.087
3.11 (0.5)
3.3 (0.7)
(−0.7, 0.3)
0.420
Responder+
19 (73.1%)
7 (29.2%)
0.020#
17 (65.4%)
5 (20.8%)
0.034#
1 (6.3%)
0 (0%)
*Statistical significance assessed at 0.05/4 = 0.0125 (Bonferroni correction) for both intention to treat () and per protocol analysis (). +Responder: participants with 50% or greater reduction in days with migraine. #Indicates statistical significance assessed at 0.05.