Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, against Aspergillus spp.

Table 1

MIC values (μg/mL) of 7-hydroxy-6-nitro-2H-1-benzopyran-2-one against clinical strains of Aspergillus spp.

Microorganisms	MIC values (μg/mL)
	A. fumigatus	A. fumigatus	A. fumigatus	A. flavus	A. flavus	A. flavus
	(LM 121)	(LM 135)	(LM 743)	(LM 35)	(LM 36)	(LM 23)
Cou-UNO2	16	32	32	16	16	16
Amphotericin B	2	2	2	2	2	2
Viability control	+	+	+	+	+	+
Negative control	−	−	−	−	−	−
Sensitivity control	+	+	+	+	+	+

Note. Cou-UNO₂: 7-hydroxy-6-nitro-2H-1-benzopyran-2-one.