Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 925432, 9 pages
http://dx.doi.org/10.1155/2015/925432
Research Article

The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice

1Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
2Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 570-749, Republic of Korea
3Department of Pharmacology, School of Medicine, Eulji University, Jung-gu, Daejeon 301-746, Republic of Korea
4Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea
5Hanpoong Pharm & Foods Co., Ltd., Jeonju 561-841, Republic of Korea
6Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University, Iksan 570-749, Republic of Korea

Received 25 August 2015; Accepted 11 October 2015

Academic Editor: Hassan Obied

Copyright © 2015 Samrat Baral et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Cummings, “The role of cholinergic agents in the management of behavioural disturbances in Alzheimer's disease,” The International Journal of Neuropsychopharmacology, vol. 3, pp. S21–S29, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Sunderland, P. Tariot, D. L. Murphy, H. Weingartner, E. A. Mueller, and R. M. Cohen, “Scopolamine challenges in Alzheimer's disease,” Psychopharmacology, vol. 87, no. 2, pp. 247–249, 1985. View at Publisher · View at Google Scholar · View at Scopus
  3. Q. Liu and J. Wu, “Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate β-amyloid neurotoxicity,” Acta Pharmacologica Sinica, vol. 27, no. 10, pp. 1277–1286, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. A. V. Terry Jr. and J. J. Buccafusco, “The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development,” Journal of Pharmacology and Experimental Therapeutics, vol. 306, no. 3, pp. 821–827, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Mayeux and M. Sano, “Treatment of Alzheimer's disease,” The New England Journal of Medicine, vol. 341, no. 22, pp. 1670–1679, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Park, D. H. Kim, I. K. Lee et al., “The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice,” Food and Chemical Toxicology, vol. 48, no. 6, pp. 1671–1676, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Geun Kim and M. Sook Oh, “Herbal medicines for the prevention and treatment of Alzheimer's disease,” Current Pharmaceutical Design, vol. 18, no. 1, pp. 57–75, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M.-J. R. Howes, N. S. L. Perry, and P. J. Houghton, “Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders,” Phytotherapy Research, vol. 17, no. 1, pp. 1–18, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. J. L. Berkeley, J. Gomeza, J. Wess, S. E. Hamilton, N. M. Nathanson, and A. I. Levey, “M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices,” Molecular and Cellular Neuroscience, vol. 18, no. 5, pp. 512–524, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Davis, P. Vanhoutte, C. Pagès, J. Caboche, and S. Laroche, “The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo,” The Journal of Neuroscience, vol. 20, no. 12, pp. 4563–4572, 2000. View at Google Scholar · View at Scopus
  11. C. R. Raymond, S. J. Redman, and M. F. Crouch, “The phosphoinositide 3-kinase and p70 S6 kinase regulate long-term potentiation in hippocampal neurons,” Neuroscience, vol. 109, no. 3, pp. 531–536, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. D. M. Barros, T. Mello E Souza, M. M. de Souza et al., “LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance,” Behavioural Pharmacology, vol. 12, no. 8, pp. 629–634, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Mizuno, K. Yamada, N. Takei et al., “Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation,” Molecular Psychiatry, vol. 8, no. 2, pp. 217–224, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Moosavi, G. Yadollahi Khales, L. Abbasi, A. Zarifkar, and K. Rastegar, “Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivation,” Neuropharmacology, vol. 62, no. 5-6, pp. 2018–2023, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. F. Xian, S. P. Ip, Q. Q. Mao et al., “Honokiol improves learning and memory impairments induced by scopolamine in mice,” European Journal of Pharmacology, vol. 760, pp. 88–95, 2015. View at Publisher · View at Google Scholar
  16. K. H. C. Başer, B. Demirci, A. Dekebo, and E. Dagne, “Essential oils of some Boswellia spp., myrrh and opopanax,” Flavour and Fragrance Journal, vol. 18, no. 2, pp. 153–156, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Zhu, S. Sheng, S. Sang, R. T. Rosen, and C.-T. Ho, “Isolation and characterization of several aromatic sesquiterpenes from Commiphora myrrha,” Flavour and Fragrance Journal, vol. 18, no. 4, pp. 282–285, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Shen, G.-H. Li, X.-N. Wang, and H.-X. Lou, “The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology,” Journal of Ethnopharmacology, vol. 142, no. 2, pp. 319–330, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. A. O. Tucker, “Frankincense and myrrh,” Economic Botany, vol. 40, no. 4, pp. 425–433, 1986. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Su, T. Wang, J.-A. Duan et al., “Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 251–258, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Xu, Y. Guo, P. Zhao et al., “Neuroprotective cadinane sesquiterpenes from the resinous exudates of Commiphora myrrha,” Fitoterapia, vol. 82, no. 8, pp. 1198–1201, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. H. Yi, H. C. Kwon, S. Z. Choi, W. B. Lee, E. J. Bang, and K. R. Lee, “Constituents of aerial parts from Erechtites heeracifolia,” Yakhak Hoeji, vol. 45, no. 4, pp. 339–346, 2001. View at Google Scholar
  23. W. N. Dember and H. Fowler, “Spontaneous alternation behavior,” Psychological Bulletin, vol. 55, no. 6, pp. 412–428, 1958. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Holcomb, M. N. Gordon, E. McGowan et al., “Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes,” Nature Medicine, vol. 4, no. 1, pp. 97–100, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. B. S. Basavarajappa and S. Subbanna, “CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations,” Hippocampus, vol. 24, no. 2, pp. 178–188, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Parada-Turska and W. A. Turski, “Excitatory amino acid antagonists and memory: effect of drugs acting at N-methyl-D-aspartate receptors in learning and memory tasks,” in Amino Acids, G. Gert Lubec and G. A. Rosenthal, Eds., pp. 745–753, Springer, Dordrecht, The Netherlands, 1990. View at Publisher · View at Google Scholar
  27. S. Pellow, P. Chopin, S. E. File, and M. Briley, “Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat,” Journal of Neuroscience Methods, vol. 14, no. 3, pp. 149–167, 1985. View at Publisher · View at Google Scholar · View at Scopus
  28. S. J. Park, D. H. Kim, J. M. Jung et al., “The ameliorating effects of stigmasterol on scopolamine-induced memory impairments in mice,” European Journal of Pharmacology, vol. 676, no. 1–3, pp. 64–70, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Xu, N. Tan, G. Zeng et al., “Studies on chemical constituents in fruit of Alpinia oxyphylla,” Zhongguo Zhongyao Zazhi, vol. 34, no. 8, pp. 990–993, 2009. View at Google Scholar · View at Scopus
  30. P. Weyerstahl, H. Marschall, M. Weirauch, K. Thefeld, and H. Surburg, “Constituents of commercial labdanum oil,” Flavour and Fragrance Journal, vol. 13, no. 5, pp. 295–318, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Sarter, G. Bodewitz, and D. N. Stephens, “Attenuation of scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and agonist β-carbolines,” Psychopharmacology, vol. 94, no. 4, pp. 491–495, 1988. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Myhrer, “Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks,” Brain Research Reviews, vol. 41, no. 2-3, pp. 268–287, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Peng, Y. Zhang, J. Zhang, H. Wang, and B. Ren, “ERK in learning and memory: a review of recent research,” International Journal of Molecular Sciences, vol. 11, no. 1, pp. 222–232, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. J. D. English and J. D. Sweatt, “A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation,” Journal of Biological Chemistry, vol. 272, no. 31, pp. 19103–19106, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. A. J. Shaywitz and M. E. Greenberg, “CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals,” Annual Review of Biochemistry, vol. 68, pp. 821–861, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. R. J. Kelleher, A. Govindarajan, H.-Y. Jung, H. Kang, and S. Tonegawa, “Translational control by MAPK signaling in long-term synaptic plasticity and memory,” Cell, vol. 116, no. 3, pp. 467–479, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. R. R. Resende and A. Adhikari, “Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation,” Cell Communication and Signaling, vol. 7, article 20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Autio, K. Mätlik, T. Rantamäki et al., “Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus,” Neuropharmacology, vol. 61, no. 8, pp. 1291–1296, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. S. J. Park, Y. J. Ahn, S. R. Oh et al., “Amyrin attenuates scopolamine-induced cognitive impairment in mice,” Biological & Pharmaceutical Bulletin, vol. 37, no. 7, pp. 1207–1213, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. M.-R. Choi, M. Y. Lee, J. E. Hong et al., “Rubus coreanus miquel ameliorates scopolamine-induced memory impairments in ICR mice,” Journal of Medicinal Food, vol. 17, no. 10, pp. 1049–1056, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. D. C. Kim, C. S. Yoon, W. M. Ko et al., “Anti-inflammatory effects of 1β‚6α-dihydroxyeudesm-4(15)-ene isolated from Myrrh on LPS-induced neuroinflammation in BV2 cells,” Korean Journal of Pharmacognosy, vol. 46, no. 1, pp. 12–16, 2015. View at Google Scholar
  42. G. Saxena, S. P. Singh, R. Pal, S. Singh, R. Pratap, and C. Nath, “Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice,” Pharmacology Biochemistry and Behavior, vol. 86, no. 4, pp. 797–805, 2007. View at Publisher · View at Google Scholar · View at Scopus