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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 926946, 9 pages
http://dx.doi.org/10.1155/2015/926946
Research Article

Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell

1Department of Nephrology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China
2Department of Emergency Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, China
3Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China

Received 20 August 2015; Accepted 28 October 2015

Academic Editor: Giuseppe Morgia

Copyright © 2015 Hong Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Signal transducer and activator of transcription factor 3 (STAT3) plays an important role in the proliferation and angiogenesis in human glioma. Previous research indicated that saw palmetto extract markedly inhibited the proliferation of human glioma cells through STAT3 signal pathway. But its effect on tumor metastasis and antiangiogenesis is not clear. This study is to further clear the impact of saw palmetto extract on glioma cell metastasis, antiangiogenesis, and its mechanism. TUNEL assay indicated that the apoptotic cells in the saw palmetto treated group are higher than that in the control group (). The apoptosis related protein is detected and the results revealed that saw palmetto extract inhibits the proliferation of human glioma. Meanwhile pSTAT3 is lower in the experimental group and CD34 is also inhibited in the saw palmetto treated group. This means that saw palmetto extract could inhibit the angiogenesis in glioma. We found that saw palmetto extract was an important phytotherapeutic drug against the human glioma through STAT3 signal pathway. Saw palmetto extract may be useful as an adjunctive therapeutic agent for treatment of individuals with glioma and other types of cancer in which STAT3 signaling is activated.