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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 931782, 9 pages
http://dx.doi.org/10.1155/2015/931782
Research Article

Luteolin Inhibits Angiotensin II-Stimulated VSMC Proliferation and Migration through Downregulation of Akt Phosphorylation

1Institute of Cardiovascular Disease Research, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu 221002, China
2Department of Cardiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China

Received 22 October 2014; Accepted 9 July 2015

Academic Editor: MinKyun Na

Copyright © 2015 Tongda Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Libby, “Inflammation in atherosclerosis,” Nature, vol. 420, no. 6917, pp. 868–874, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Alvarez, B. K. Rodiño-Janeiro, R. Ucieda-Somoza, and J. R. González-Juanatey, “Pravastatin counteracts angiotensin II-induced upregulation and activation of nadph oxidase at plasma membrane of human endothelial cells,” Journal of Cardiovascular Pharmacology, vol. 55, no. 2, pp. 203–212, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Herr, M. Rodewald, H. M. Fraser et al., “Regulation of endothelial proliferation by the renin-angiotensin system in human umbilical vein endothelial cells,” Reproduction, vol. 136, no. 1, pp. 125–130, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. A. C. Doran, N. Meller, and C. A. McNamara, “Role of smooth muscle cells in the initiation and early progression of atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 5, pp. 812–819, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Gorenne, M. Kavurma, S. Scott, and M. Bennett, “Vascular smooth muscle cell senescence in atherosclerosis,” Cardiovascular Research, vol. 72, no. 1, pp. 9–17, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Zhang, K. Peppel, P. Sivashanmugam et al., “Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 5, pp. 1087–1094, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Balakumar, T. Kaur, and M. Singh, “Potential target sites to modulate vascular endothelial dysfunction: current perspectives and future directions,” Toxicology, vol. 245, no. 1-2, pp. 49–64, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Miyamoto, M. Rubio, and M. A. Sussman, “Nuclear and mitochondrial signalling Akts in cardiomyocytes,” Cardiovascular Research, vol. 82, no. 2, pp. 272–285, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Fernández-Hernando, E. Ackah, J. Yu et al., “Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease,” Cell Metabolism, vol. 6, no. 6, pp. 446–457, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Cicenas, “The potential role of Akt phosphorylation in human cancers,” International Journal of Biological Markers, vol. 23, no. 1, pp. 1–9, 2008. View at Google Scholar · View at Scopus
  11. J. Limón-Pacheco and M. E. Gonsebatt, “The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 674, no. 1-2, pp. 137–147, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. B.-Y. Cha, W. L. Shi, T. Yonezawa, T. Teruya, K. Nagai, and J.-T. Woo, “An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells,” Journal of Pharmacological Sciences, vol. 110, no. 1, pp. 105–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Benavente-García and J. Castillo, “Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity,” Journal of Agricultural and Food Chemistry, vol. 56, no. 15, pp. 6185–6205, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. López-Lázaro, “Distribution and biological activities of the flavonoid luteolin,” Mini-Reviews in Medicinal Chemistry, vol. 9, no. 1, pp. 31–59, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Zhao, C. Li, J.-G. Cao et al., “7-Difluoromethyl-5,4′-dimethoxygenistein, a novel genistein derivative, has therapeutic effects on atherosclerosis in a rabbit model,” Journal of Cardiovascular Pharmacology, vol. 54, no. 5, pp. 412–420, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Brusselmans, R. Vrolix, G. Verhoeven, and J. V. Swinnen, “Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity,” The Journal of Biological Chemistry, vol. 280, no. 7, pp. 5636–5645, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Terao, “Dietary flavonoids as antioxidants,” Forum of Nutrition, vol. 61, pp. 87–94, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Fang, D. Li, H. Pan et al., “Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion,” Pharmacology, vol. 88, no. 3-4, pp. 149–158, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Qi, H. Pan, D. Li, F. Fang, D. Chen, and H. Sun, “Luteolin improves contractile function and attenuates apoptosis following ischemia-reperfusion in adult rat cardiomyocytes,” European Journal of Pharmacology, vol. 668, no. 1-2, pp. 201–207, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Sun, J. Huang, Z. Zhang et al., “Luteolin limits infarct size and improves cardiac function after myocardium ischemia/reperfusion injury in diabetic rats,” PLoS ONE, vol. 7, no. 3, Article ID e33491, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Song, K. Liu, J. Yi, D. Zhu, G. Liu, and B. Liu, “Luteolin inhibits lysophosphatidylcholine-induced apoptosis in endothelial cells by a calcium/mithocondrion/caspases-dependent pathway,” Planta Medica, vol. 76, no. 5, pp. 433–438, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Zhu, D. Chen, D. Li et al., “Luteolin inhibits angiotensin II-induced human umbilical vein endothelial cell proliferation and migration through downregulation of src and Akt phosphorylation,” Circulation Journal, vol. 77, no. 3, pp. 772–779, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Lang, D. Chen, D. Li et al., “Luteolin inhibited hydrogen peroxide-induced vascular smooth muscle cells proliferation and migration by suppressing the Src and Akt signalling pathways,” Journal of Pharmacy and Pharmacology, vol. 64, no. 4, pp. 597–603, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Zhao, A. Q. Li, T. F. Zhou, M. Q. Zhang, and X. M. Qin, “Exendin-4 alleviates angiotensin II-induced senescence in vascular smooth muscle cells by inhibiting Rac1 activation via a cAMP/PKA-dependent pathway,” The American Journal of Physiology—Cell Physiology, vol. 307, no. 12, pp. C1130–C1141, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. C. E. Schreiner, M. Kumerz, J. Gesslbauer et al., “Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner,” Cardiovascular Research, vol. 90, no. 1, pp. 140–147, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Ni, Y. Zhan, H. He, E. Maynard, J. A. Balschi, and P. Oettgen, “Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47phox gene expression in response to angiotensin II,” Circulation Research, vol. 101, no. 10, pp. 985–994, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. D. S. Weber, P. Rocic, A. M. Mellis et al., “Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 288, no. 1, pp. H37–H42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Dimmeler and A. M. Zeiher, “Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors,” Regulatory Peptides, vol. 90, no. 1–3, pp. 19–25, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. C. K. Singh, S. Kaur, J. George et al., “Molecular signatures of sanguinarine in human pancreatic cancer cells: a large scale label-free comparative proteomics approach,” Oncotarget, vol. 6, no. 12, pp. 10335–10348, 2015. View at Google Scholar
  30. M. Yang, X. Zhai, B. Xia, Y. Wang, and G. Lou, “Long noncoding RNA CCHE1 promotes cervical cancer cell proliferation via upregulating PCNA,” Tumor Biology, 2015. View at Publisher · View at Google Scholar