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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 947619, 11 pages
http://dx.doi.org/10.1155/2015/947619
Review Article

Chemical Components and Cardiovascular Activities of Valeriana spp.

1Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
2Hubei University of Traditional Chinese Medicine, Wuhan, Hubei 430062, China
3Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China
4Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, Heilongjiang 150036, China

Received 29 September 2015; Revised 16 November 2015; Accepted 19 November 2015

Academic Editor: William C. Cho

Copyright © 2015 Heng-Wen Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H.-B. Chen and J.-R. Cheng, “Taxonomic revision of the relative species of Valeriana officinalis Linn. from China,” Bulletin of Botanical Research, vol. 3, pp. 29–40, 1991. View at Google Scholar
  2. H. B. Chen and J. R. Cheng, “Studies on the medicinal plants of Valerianaceae in China,” China Journal of Chinese Materia Medica, vol. 2, no. 3, pp. 67–70, 1994. View at Google Scholar · View at Scopus
  3. P.-J. Houghton, “The biological activity of valerian and related plants,” Journal of Ethnopharmacology, vol. 22, no. 2, pp. 121–142, 1988. View at Publisher · View at Google Scholar · View at Scopus
  4. P. J. Houghton, “The scientific basis for the reputed activity of Valerian,” The Journal of Pharmacy and Pharmacology, vol. 51, no. 5, pp. 505–512, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Muller, T. Pfeil, and V. von den Driesch, “Valeriana officinalis (monograph),” Alternative Medicine Review, vol. 9, no. 4, pp. 438–441, 2004. View at Google Scholar
  6. P.-W. Thies, “Zur Konstitution der isovalerian saureester valepotriat, acetoxyvalepotriat und dihydrovalepotriat,” Tetrahedron Letters, vol. 7, no. 11, pp. 1163–1170, 1966. View at Google Scholar
  7. H. Hendriks, H.-J. Geertsma, and T.-M. Malingre, “The occurrence of valeranone and crytofauronol in the essential oil of Valeriana officinalis cinalis L. collected in the northern part of the Netherlands,” Pharmaceutisch Weekblad Scientific Edition, vol. 116, pp. 1316–1320, 1981. View at Google Scholar
  8. P. D. Leathwood, F. Chauffard, E. Heck, and R. Munoz-Box, “Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man,” Pharmacology, Biochemistry and Behavior, vol. 17, no. 1, pp. 65–71, 1982. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Sakamoto, Y. Mitani, and K. Nakajima, “Psychotropic effects of Japanese Valerian root extract,” Chemical and Pharmaceutical Bulletin, vol. 40, no. 3, pp. 758–761, 1992. View at Publisher · View at Google Scholar · View at Scopus
  10. M.-S. Santos, F. Ferreira, C. Faro et al., “The amount of GABA present in aqueous extracts of valerian is sufficient to account for [3H] GABA release in synaptosomes,” Planta Medica, vol. 60, no. 5, pp. 475–476, 1994. View at Google Scholar
  11. Z.-X. Zhang and X.-S. Yao, “The advance of chemical study on the medicinal plant Valeriana officinalis L.,” Chinese Journal of Medicinal Chemistry, no. 3, pp. 226–229, 2000. View at Google Scholar
  12. X.-G. Liu, P.-Y. Gao, G.-S. Wang et al., “In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana faurieiBriq,” Fitoterapia, vol. 83, no. 3, pp. 599–603, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. Q.-H. Wang, C.-F. Wang, Y.-M. Zuo, Z.-B. Wang, B.-Y. Yang, and H.-X. Kuang, “Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells,” Molecules, vol. 17, no. 12, pp. 15013–15021, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. S. M. Nam, J. H. Choi, D. Y. Yoo et al., “Valeriana officinalis extract and its main component, valerenic acid, ameliorate d-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation,” Experimental Gerontology, vol. 48, no. 11, pp. 1369–1377, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Felgentreff, A. Becker, B. Meier, and A. Brattström, “Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity,” Phytomedicine, vol. 19, no. 13, pp. 1216–1222, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. Q.-H. Wang, C.-F. Wang, Z.-P. Shu et al., “Valeriana amurensis improves Amyloid-beta 1-42 induced cognitive deficit by enhancing cerebral cholinergic function and protecting the brain neurons from apoptosis in mice,” Journal of Ethnopharmacology, vol. 153, no. 2, pp. 318–325, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Sridharan, K. Mohankumar, S. P. Jeepipalli et al., “Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice,” Neurotoxicology, vol. 51, pp. 172–183, 2015. View at Publisher · View at Google Scholar
  18. W. Letchamo, W. Ward, B. Heard, and D. Heard, “Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation,” Journal of Agricultural and Food Chemistry, vol. 52, no. 12, pp. 3915–3919, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. Y.-D. Chen and C.-H. Gu, “Study on the chemical composition of essential oil from Valeriana Officinalis L,” Chemistry and Industry of Forest Products, vol. 9, pp. 59–64, 1989. View at Google Scholar
  20. C.-H. Gu, L. Gu, and Y.-K. Zhang, “Comparison study on essential oil from wild and cultivated Valeriana pseudofficinalis by GC/MS anaylsis,” Chemistry and Industry of Forest Products, vol. 19, pp. 64–69, 1999. View at Google Scholar
  21. B.-K. Huang, L.-P. Qin, Q.-C. Chu, Q.-Y. Zhang, L.-H. Gao, and H.-C. Zheng, “Comparison of headspace spme with hydrodistillation and sfe for analysis of the volatile components of the roots of Valeriana officinalis var. latifolia,” Chromatographia, vol. 69, no. 5-6, pp. 489–496, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J.-L. Shi, Y. Liu, and P.-G. Xiao, “The chemical constituents and bioactivities of Valeriana officinlais L.,” World Phytomedicines, vol. 18, no. 6, pp. 231–239, 2003. View at Google Scholar
  23. M. Pavlovic, N. Kovacevic, O. Tzakou, and M. Couladis, “The essential oil of Valeriana officinalis L. s.l. growing wild in Western Serbia,” Journal of Essential Oil Research, vol. 16, no. 5, pp. 397–399, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Bos, H. Hendriks, N. Pras, A.-S. Stojanova, and E. V. Georgiev, “Essential oil composition of Valeriana officinalis ssp. collina cultivated in Bulgaria,” Journal of Essential Oil Research, vol. 12, no. 3, pp. 313–316, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. C.-Z. Long, H.-L. Xiao, and J.-Q. Peng, “Chemical constituents of the volatile oil from Valeriana officinalis Linn. var. Latifolia Miq grown in guizhou province,” Acta Botanica Yunnanica, vol. 9, no. 1, pp. 109–112, 1987. View at Google Scholar
  26. D.-S. Ming, J.-X. Guo, and Q.-S. Shun, “Determination of chemical composition of the essential oil from four kinds of Valeriana officinalis L. by GC/MS,” Chinese Traditional Patent Medicine, vol. 16, no. 1, pp. 41–42, 1994. View at Google Scholar
  27. L.-Q. Wang, Y.-T. Xiong, F.-H. Tao, and N.-Q. Li, “Chemical constituents of essential oil from Valeriana officinalis Linn. var. Latifolia Miq,” China Journal of Chinese Materia Medica, vol. 22, no. 6, pp. 298–299, 1999. View at Google Scholar
  28. Z.-W. Yu, Z.-N. Yang, and Y. Yi, “Analysis of chemical constituents of essential oil from cultured Valeriana officinalis L.,” Chinese Journal of Spectroscopy Laboratory, vol. 28, no. 4, pp. 1672–1674, 2011. View at Google Scholar
  29. P.-W. Thies and S. Funke, “Active principles of baldrian. I. Detection and isolation of the sedative active isovalerianic acid esters from roots and rhizomes of various Valerian and Centranthus species,” Tetrahedron Letters, vol. 7, no. 11, pp. 1155–1162, 1966. View at Publisher · View at Google Scholar
  30. L. Chen, L.-P. Qin, and H.-C. Zheng, “Chemical constituents, plant resource and pharmacology-activity on the Valeriana officinalis L,” Journal of Pharmaceutical Practice, vol. 18, no. 5, pp. 277–279, 2000. View at Google Scholar
  31. S. Lin, T. Chen, X.-H. Liu et al., “Iridoids and lignans from Valeriana jatamansi,” Journal of Natural Products, vol. 73, no. 4, pp. 632–638, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Schumacher, S. Scholle, J. Hölzl, N. Khudeir, S. Hess, and C. E. Müller, “Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A1 adenosine receptors,” Journal of Natural Products, vol. 65, no. 10, pp. 1479–1485, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. A. L. Piccinelli, S. Arana, A. Caceres, R. D. di Villa Bianca, R. Sorrentino, and L. Rastrelli, “New lignans from the roots of Valeriana prionophylla with antioxidative and vasorelaxant activities,” Journal of Natural Products, vol. 67, no. 7, pp. 1135–1140, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. I.-P. Nazarova, A.-I. Glushenkova, and A.-U. Umarov, “Gossypol-like compounds of the cotton plant. Methods of determining gossypol,” Chemistry of Natural Compounds, vol. 17, no. 2, pp. 87–102, 1981. View at Publisher · View at Google Scholar · View at Scopus
  35. P.-W. Thies, E. Finner, and F. Rosskopf, “Über die wirkstoffe des baldrians—X: die konfiguration des valtratum und anderer valepotriate,” Tetrahedron, vol. 29, no. 20, pp. 3213–3226, 1973. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Popov, N. Handjieva, and N. Marekov, “A new valepotriate, 7-epi-deacetylisovaltrate from Valeriana officinalis,” Phytochemistry, vol. 13, no. 12, pp. 2815–2818, 1974. View at Publisher · View at Google Scholar · View at Scopus
  37. P.-W. Thies, “Constitution of valepotriates. Report on active agents of valerian,” Tetrahedron, vol. 24, no. 1, pp. 313–347, 1968. View at Google Scholar
  38. J. Holzl and U. Koch, “The compounds of Valeriana alliariifolia. 1-β-acevaltratum, a new valepotriate,” Planta Medica, vol. 50, no. 5, p. 458, 1984. View at Google Scholar
  39. U. Koch and J. Hoelzl, “Constituents of Valeriana alliariifolia. 2. Valepotriathydrines,” Planta Medica, vol. 51, no. 2, pp. 172–173, 1985. View at Publisher · View at Google Scholar
  40. L.-A. Salles, A. L. Silva, S. B. Rech, N. Zanatta, and G. L. Von Poser, “Constituents of Valeriana glechomifolia Meyer,” Biochemical Systematics and Ecology, vol. 28, no. 9, pp. 907–910, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Becker and S. Chavadej, “Tissue cultures of Valerianaceae. 7. Valepotriate production of normal and colchicine-treated cell-suspension cultures of Valeriana Wallichii,” Journal of Natural Products, vol. 48, no. 1, pp. 17–21, 1985. View at Google Scholar
  42. Y. Amanzadeh, N. Ghassemi-Dehkordi, S. E. Sadat-Ebrahimi, and M. Pirali-Hamedani, “Two new valepotriates from the roots of Valeriana sisymbriifolia,” DARU Journal of Pharmaceutical Sciences, vol. 10, no. 2, pp. 63–66, 2002. View at Google Scholar · View at Scopus
  43. N. Fuzzati, J. L. Wolfender, K. Hostettmann, J. D. Msonthi, S. Mavi, and L. P. Molleyres, “Isolation of antifungal valepotriates from Valeriana capense and the search for valepotriates in crude Valerianaceae extracts,” Phytochemical Analysis, vol. 7, no. 2, pp. 76–85, 1996. View at Google Scholar · View at Scopus
  44. Y. Tang, X. Liu, and B. Yu, “Iridoids from the rhizomes and roots of Valeriana jatamansi,” Journal of Natural Products, vol. 65, no. 12, pp. 1949–1952, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. Y.-M. Xu, S.-P. McLaughlin, and A. A. L. Gunatilaka, “Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia,” Journal of Natural Products, vol. 70, no. 12, pp. 2045–2048, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. P.-W. Thies, E. Finner, and S. David, “On the active agents of valerian.14. assignment of type and location of the acyloxy substituents in valepotriates via 13C-NMR spectroscopy,” Planta Medica, vol. 41, no. 1, pp. 15–20, 1981. View at Google Scholar
  47. J. Holzl, V.-M. Chari, and O. Seligmann, “Structure of 3 genuine valtrate hydrines from Valeriana tiliaefolia,” Tetrahedron Letters, vol. 17, no. 15, pp. 1171–1174, 1976. View at Publisher · View at Google Scholar
  48. R. Wang, D. Xiao, Y.-H. Bian et al., “Minor iridoids from the roots of Valeriana wallichii,” Journal of Natural Products, vol. 71, no. 7, pp. 1254–1257, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Lin, Y.-H. Shen, H.-A. Li et al., “Acylated iridoids with cytotoxicity from Valeriana jatamansi,” Journal of Natural Products, vol. 72, no. 4, pp. 650–655, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Xu, P. Guo, L.-Z. Fang, Y.-S. Li, and Y.-Q. Guo, “Iridoids from the roots of Valeriana jatamansi,” Journal of Asian Natural Products Research, vol. 14, no. 1, pp. 1–6, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. J. Xu, P. Zhao, Y.-Q. Guo et al., “Iridoids from the roots of Valeriana jatamansi and their neuroprotective effects,” Fitoterapia, vol. 82, no. 7, pp. 1133–1136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Xu, Y.-Q. Guo, D.-Q. Jin et al., “Three new iridoids from the roots of Valeriana jatamansi,” Journal of Natural Medicines, vol. 66, no. 4, pp. 653–657, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. K.-K. Bach, F. Ghia, and K.-B.-G. Torssell, “Valtrates and lignans in Valeriana microphylla,” Planta Medica, vol. 59, no. 5, pp. 478–479, 1993. View at Publisher · View at Google Scholar · View at Scopus
  54. W. Kucaba, P.-W. Thies, and E. Finner, “Isodidrovaltratum, ein neues valepotriat aus Valeriana vaginata,” Phytochemistry, vol. 19, no. 4, pp. 575–577, 1980. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Yu, R. Huang, C. Han, Y. Lv, Y. Zhao, and Y. Chen, “New iridoid triesters from Valeriana jatamansi,” Helvetica Chimica Acta, vol. 88, no. 5, pp. 1059–1062, 2005. View at Publisher · View at Google Scholar · View at Scopus
  56. L.-L. Yu, C.-R. Han, R. Huang, Y.-P. Lv, S.-H. Gui, and Y.-G. Chen, “A new iridoid tetraester from Valeriana jatamansi,” Pharmazie, vol. 61, no. 5, pp. 486–488, 2006. View at Google Scholar · View at Scopus
  57. P.-C. Wang, J.-M. Hu, X.-H. Ran et al., “Iridoids and sesquiterpenoids from the roots of Valeriana officinalis,” Journal of Natural Products, vol. 72, no. 9, pp. 1682–1685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. J. Xu, P. Guo, Y. Guo et al., “Iridoids from the roots of Valeriana jatamansi and their biological activities,” Natural Product Research, vol. 26, no. 21, pp. 1996–2001, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. B.-K. Huang, H.-C. Zheng, and L.-P. Qin, “Material basis of the sedative and hypnotic activities of Valeriana officinalis,” Pharmaceutical Care and Research, vol. 6, no. 3, pp. 165–168, 2006. View at Google Scholar · View at Scopus
  60. B. Wu, Y.-M. Fu, A.-H. Huang, and Y.-J. Ma, “Changes of GABA and Glu content in hippocampus of PTZ-induced epileptic rats treated with volatile oil of Valeriana,” Chinese Archives of Traditional Chinese Medicine, vol. 26, no. 11, pp. 2476–2477, 2008. View at Google Scholar
  61. J.-S. Chen, J.-K. Wu, L. Liu, Y. Zhang, F.-J. Wang, and X.-W. Du, “Studies on improving sleep function and relative mechanism of mice by petroleum extract of Valeriana amurensis,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 19, no. 24, pp. 245–249, 2013. View at Google Scholar
  62. Z.-X. Zhang and X.-S. Yao, “The development and research advances in bio-activity for the medicinal plant Valeriana officinalis,” Journal of Shenyang Pharmaceutical University, no. 1, pp. 222–225, 2000. View at Google Scholar
  63. J.-F. Wang, G.-Y. Yang, and J.-N. Wang, “Effects of Valeriana officinalis var Latifolia Miq on the migration of cultured human vascular smooth muscle cells,” Journal of Yunyang Medical College, vol. 18, no. 4, pp. 196–197, 1999. View at Google Scholar
  64. G.-Y. Yang, Q. Xu, and J.-F. Wang, “Valeriana officinalis var. Latifolia Miq regulates vascular smooth muscle cell contraction and growth,” Journal of Yunyang Medical College, vol. 21, no. 6, pp. 324–326, 2002. View at Google Scholar
  65. X.-Z. Zhou, L. Kang, Y. Kang, L. Li, and S.-H. Xiong, “Effect of Valeriana Officinalis Var Latifolia Miq on heart rat and arterial blood pressure of rabbit,” Journal of Liaoning University of TCM, vol. 11, no. 12, pp. 188–189, 2009. View at Google Scholar
  66. A.-M. Fields, T.-A. Richards, J.-A. Felton et al., “Analysis of responses to valerian root extract in the feline pulmonary vascular bed,” Journal of Alternative and Complementary Medicine, vol. 9, no. 6, pp. 909–918, 2003. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Estrada-Soto, J. Rivera-Leyva, J.-J. Ramírez-Espinosa, P. Castillo-España, F. Aguirre-Crespo, and O. Hernández-Abreu, “Vasorelaxant effect of Valeriana edulis ssp. procera (Valerianaceae) and its mode of action as calcium channel blocker,” Journal of Pharmacy and Pharmacology, vol. 62, no. 9, pp. 1167–1174, 2010. View at Publisher · View at Google Scholar · View at Scopus
  68. B.-H. Zhang, H.-P. Meng, T. Wang et al., “Effects of Valeriana officinalis L. extract on cardiovascular system,” Acta Pharmaceutica Sinica, vol. 17, no. 5, pp. 382–384, 1982. View at Google Scholar · View at Scopus
  69. J. Yang, C.-K. Xue, X.-Z. Zhu et al., “Evaluate the effect of some TCMs extracts on improving micro circulation reperfusion volume of both cardiac and renal tissues by 86Rb tracer,” Chinese Journal of Microcirculation, vol. 8, no. 1, pp. 15–17, 1998. View at Google Scholar
  70. Z.-R. Huang, Q.-Z. Tang, W.-H. Li, L.-J. Zhang, Q. Xie, and G. Wu, “Study of monoterpene oxide pretreatment on donor heart preservation,” Chinese Heart Journal, vol. 18, no. 2, pp. 182–184, 2006. View at Google Scholar
  71. S.-H. Yang, F. Chen, H.-M. Ma, and T. Wang, “Protection of Valeriana officinalis L. extract preconditioning on ischemia-reperfusion injury in rat hearts in vitro,” Medical Journal of Wuhan University, vol. 33, no. 5, pp. 639–643, 2012. View at Google Scholar · View at Scopus
  72. H. Wang, S.-D. Luo, H.-S. Cai, F. Wang, and J. Yang, “Antiarrhythmic effect of diacetyl-linesinine,” Chinese Journal of Hospital. Pharmacy, vol. 21, no. 6, pp. 326–330, 2001. View at Google Scholar
  73. D.-M. Gong, H.-L. Shan, D.-L. Dong, H.-Y. Zhou, and B.-F. Yang, “Study of ion targets in Ouabain-induced rat arrhythmia,” Journal of Harbin Medical University, vol. 36, no. 2, pp. 87–90, 2002. View at Google Scholar
  74. J.-N. Jia and B.-H. Zhang, “Effects of extract of Valeriana officinalis L. (V3d) on cardiovascular system,” Journal of Guangxi University of Chinese Medicine, vol. 16, no. 1, pp. 40–42, 1999. View at Google Scholar
  75. Z.-R. Huang, Effect of Valerian Extract on Ionic Channels of Rabbit Ventricular Myocytes, Wuhan University, Wuhan, China, 2004.
  76. L. Wen, Y. Zhou, W. Zhou, X.-Y. Duan, and Y. Fang, “Effect of extracts of Valeriana officinalis L. on cardiac arrhythmias,” Chinese Journal of Hospital Pharmacy, vol. 29, no. 3, pp. 191–194, 2009. View at Google Scholar
  77. X.-Y. Duan, Study on the Drug Effect Substances and the Mechanism of Arrhythmic Effects of Valeriana officinalis L., Hubei College of TCM, Wuhan, China, 2009.
  78. Q. Xie, W.-H. Li, Z. R. Huang, and Z. Zhang, “Effect of didrovaltrate on l-calcium current in rabbit ventricular myocytes,” Journal of Traditional Chinese Medicine, vol. 32, no. 3, pp. 442–445, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. J.-F. Liu, Y. Fang, Z.-F. Gong, Y.-W. Liu, and J.-F. Jiu, “Study on the anti-arrhythmia effective substances and serum pharmacochemistry of Valeriana officinalis L,” Hubei Journal of Traditional Chinese Medicine, vol. 35, no. 1, pp. 72–73, 2013. View at Google Scholar
  80. C.-X. Hu, D.-B. Zhang, H. Li et al., “Effects of Valeriana officinalis L. var Latifolia Miq on blood-lipid metabolism in rabbits with hyperlipidemia,” Journal of Nanjing Military Medical College, vol. 21, no. 2, pp. 65–68, 1999. View at Google Scholar
  81. X.-Y. Si, R.-H. Jia, C.-X. Huang, G.-H. Ding, and H.-Y. Liu, “Effects of Valeriana officinalis var. latifolia on expression of transforming growth factor β1 in hypercholesterolemic rats,” China Journal of Chinese Materia Medica, vol. 28, no. 9, pp. 845–848, 2003. View at Google Scholar