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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 956750, 9 pages
http://dx.doi.org/10.1155/2015/956750
Research Article

Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOF/MS

1Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China
2Respiratory Disease Institute, The First Affiliated Hospital of Henan University of TCM, Zhengzhou 450000, China

Received 10 November 2014; Revised 15 February 2015; Accepted 27 February 2015

Academic Editor: Young Hae Choi

Copyright © 2015 Liping Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. F. Rabe, S. Hurd, A. Anzueto et al., “Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary,” American Journal of Respiratory and Critical Care Medicine, vol. 176, no. 6, pp. 532–555, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Guo, S. Li, Z. Tian, X. Pan, J. Zhang, and G. Williams, “The burden of air pollution on years of life lost in Beijing, China, 2004–08: retrospective regression analysis of daily deaths,” British Medical Journal, vol. 347, Article ID f7139, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Zhong, C. Wang, W. Yao et al., “Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey,” The American Journal of Respiratory and Critical Care Medicine, vol. 176, no. 8, pp. 753–760, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. C. J. L. Murray and A. D. Lopez, “Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study,” The Lancet, vol. 349, no. 9064, pp. 1498–1504, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Wang, “Drug treatment and development of COPD,” Chinese Journal of Urban and Rural Industrial Hygiene, vol. 6, no. 3, pp. 22–23, 2006. View at Google Scholar
  6. P. B. Wu and J. G. Hu, “Application of β2 receptor agonists in the treatment of respiratory diseases,” Journal of Clinical Pulmonary Medicine, vol. 15, no. 6, pp. 993–994, 2010. View at Google Scholar
  7. K. Ito, S. Lim, G. Caramori et al., “A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 13, pp. 8921–8926, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. R. N. J. De Nijs, “Glucocorticoid-induced osteoporosis: a review on pathophysiology and treatment options,” Minerva Medica, vol. 99, no. 1, pp. 23–43, 2008. View at Google Scholar · View at Scopus
  9. M. Z. Guo, Z. X. Yang, and Y. Q. Xiao, “Development of the study on the effects of Chinese herbs in treating COPD,” Chinese Medicine and Pharmacology, vol. 37, no. 5, p. 105, 2009. View at Google Scholar
  10. Q. Chen and S. M. Liu, “Study on the changes of blood rheology and the interfere effect of herbs with invigorating qi and promoting blood circulation effect in patients with chronic obstructive pulmonary disease,” Hunan Journal of Traditional Chinese Medicine, vol. 21, no. 3, pp. 3–7, 2005. View at Google Scholar
  11. C. Y. Tang, L. Lin, and Y. J. Xu, “Effects of strengthening earth to support metal on nutrition and lung function in stable COPD patients,” Journal of Nanjing University of Traditional Chinese Medicine, vol. 21, no. 3, p. 16, 2005. View at Google Scholar
  12. G. Xiong, S. Chen, W. Xie, X. D. Ye, and J. Lin, “Effects of Shenge powder on lung function, the level of serum IL-8, TNF-α in stable COPD,” Chinese Journal of Geriatric Care, vol. 6, no. 4, pp. 37–39, 2008. View at Google Scholar
  13. J. Li, L. Yang, Q. Yao et al., “Effects and mechanism of Bufei Yishen formula in a rat chronic obstructive pulmonary disease model,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 381976, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. J. K. Nicholson, J. C. Lindon, and E. Holmes, “‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data,” Xenobiotica, vol. 29, no. 11, pp. 1181–1189, 1999. View at Google Scholar · View at Scopus
  15. Y.-M. Lao, J.-G. Jiang, and L. Yan, “Application of metabonomic analytical techniques in the modernization and toxicology research of traditional chinese medicine,” British Journal of Pharmacology, vol. 157, no. 7, pp. 1128–1141, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. X. Wang, H. Sun, A. H. Zhang, W. J. Sun, P. Wang, and Z. G. Wang, “Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine,” Journal of Pharmaceutical and Biomedical Analysis, vol. 55, no. 5, pp. 859–868, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Jonsson, E. S. Johansson, A. Wuolikainen et al., “Predictive metabolite profiling applying hierarchical multivariate curve resolution to GC-MS data—a potential tool for multi-parametric diagnosis,” Journal of Proteome Research, vol. 5, no. 6, pp. 1407–1414, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. P. R. Chen, L. Cui, and J. F. Hou, “Advances in research on development of animal models of chronic obstructive pulmonary disease,” Acta Laboratorium Animalis Scientia Sinica, vol. 15, no. 5, pp. 238–242, 2007. View at Google Scholar
  19. J. Xia and D. S. Wishart, “MetPA: a web-based metabolomics tool for pathway analysis and visualization,” Bioinformatics, vol. 26, no. 18, Article ID btq418, pp. 2342–2344, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. A. J. Duffield-Lillico, J. O. Boyle, X. K. Zhou et al., “Levels of prostaglandin E metabolite and leukotriene E4 are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway,” Cancer Prevention Research (Phila), vol. 2, no. 4, pp. 322–329, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Feltenmark, N. Gautam, Å. Brunnström et al., “Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 2, pp. 680–685, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Balode, G. Strazda, N. Jurka et al., “Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease,” Medicina, vol. 48, no. 6, pp. 292–298, 2012. View at Google Scholar · View at Scopus
  23. P. Drakatos, D. Lykouras, F. Sampsonas, K. Karkoulias, and K. Spiropoulos, “Targeting leukotrienes for the treatment of COPD?” Inflammation & Allergy: Drug Targets, vol. 8, no. 4, pp. 297–306, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Q. Gan, S. F. P. Man, A. Senthilselvan, and D. D. Sin, “Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis,” Thorax, vol. 59, no. 7, pp. 574–580, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. J. M. Moré, D. R. Voelker, L. J. Silveira, M. G. Edwards, E. D. Chan, and R. P. Bowler, “Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease,” BMC Pulmonary Medicine, vol. 10, article 53, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Matsuyama, H. Mitsuyama, M. Watanabe et al., “Effects of omega-3 polyunsaturated fatty acids on inflammatory markers in COPD,” Chest, vol. 128, no. 6, pp. 3817–3827, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. A. P. Simopoulos, “Essential fatty acids in health and chronic disease,” The American Journal of Clinical Nutrition, vol. 70, no. 3, supplement, pp. 560S–569S, 1999. View at Google Scholar
  28. L. Wang, “Drug treatment and development of COPD,” Chinese Journal of Urban and Rural Industrial Hygiene, vol. 6, pp. 22–23, 2006. View at Google Scholar
  29. I. A. Yang, M. S. Clarke, E. H. Sim, and K. M. Fong, “Inhaled corticosteroids for stable chronic obstructive pulmonary disease,” The Cochrane Database of Systematic Reviews, vol. 7, Article ID CD002991, 2012. View at Google Scholar
  30. D. D. Sin and H. Y. Park, “Steroids for treatment of COPD exacerbations: less is clearly more,” The Journal of the American Medical Association, vol. 309, no. 21, pp. 2272–2273, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. B. K. Ubhi, J. H. Riley, P. A. Shaw et al., “Metabolic profiling detects biomarkers of protein degradation in COPD patients,” European Respiratory Journal, vol. 40, no. 2, pp. 345–355, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. M. P. K. J. Engelen, C. L. N. De Castro, E. P. A. Rutten, E. F. M. Wouters, A. M. W. J. Schols, and N. E. P. Deutz, “Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids,” Clinical Nutrition, vol. 31, no. 5, pp. 616–624, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. R. K. Thimmulappa, X. Gang, J.-H. Kim, T. E. Sussan, J. L. Witztum, and S. Biswal, “Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke,” Biochemical and Biophysical Research Communications, vol. 426, no. 2, pp. 253–259, 2012. View at Publisher · View at Google Scholar · View at Scopus