Research Article

Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOF/MS

Table 3

Pathway enrichment analysis using MetPA.

TimePathwayTotal Cmpd.BiomarkerP valueImpact

Week 20Biosynthesis of unsaturated fatty acids4220.0167290
Phenylalanine, tyrosine, and tryptophan biosynthesis410.0198430
Linoleic acid metabolism510.0247511
Phenylalanine metabolism910.0441720.24074
Arachidonic acid metabolism3610.16680.32601
Steroid hormone biosynthesis7010.301850.0068

Week 32Glycerophospholipid metabolism3020.0025870.04444
Sphingolipid metabolism2110.0586430.14286
Arachidonic acid metabolism3610.0989230.32601
Biosynthesis of unsaturated fatty acids4210.114670