Research Article
Identification of Metabolites and Metabolic Pathways Related to Treatment with Bufei Yishen Formula in a Rat COPD Model Using HPLC Q-TOF/MS
Table 3
Pathway enrichment analysis using MetPA.
| Time | Pathway | Total Cmpd. | Biomarker | P value | Impact |
| Week 20 | Biosynthesis of unsaturated fatty acids | 42 | 2 | 0.016729 | 0 | Phenylalanine, tyrosine, and tryptophan biosynthesis | 4 | 1 | 0.019843 | 0 | Linoleic acid metabolism | 5 | 1 | 0.024751 | 1 | Phenylalanine metabolism | 9 | 1 | 0.044172 | 0.24074 | Arachidonic acid metabolism | 36 | 1 | 0.1668 | 0.32601 | Steroid hormone biosynthesis | 70 | 1 | 0.30185 | 0.0068 |
| Week 32 | Glycerophospholipid metabolism | 30 | 2 | 0.002587 | 0.04444 | Sphingolipid metabolism | 21 | 1 | 0.058643 | 0.14286 | Arachidonic acid metabolism | 36 | 1 | 0.098923 | 0.32601 | Biosynthesis of unsaturated fatty acids | 42 | 1 | 0.11467 | 0 |
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