Evidence-Based Complementary and Alternative Medicine

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Linked References

1. A. Doble, “The role of excitotoxicity in neurodegenerative disease: implications for therapy,” Pharmacology and Therapeutics, vol. 81, no. 3, pp. 163–221, 1999. View at Publisher · View at Google Scholar · View at Scopus
2. J. W. Olney, “Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate,” Science, vol. 164, no. 3880, pp. 719–721, 1969. View at Publisher · View at Google Scholar · View at Scopus
3. C. E. Herron, R. A. J. Lester, E. J. Coan, and G. L. Collingridge, “Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism,” Nature, vol. 322, no. 6076, pp. 265–268, 1986. View at Publisher · View at Google Scholar · View at Scopus
4. N. M. Zahr, E. L. F. Crawford, O. Hsu et al., “In vivo glutamate decline associated with kainic acid-induced status epilepticus,” Brain Research, vol. 1300, pp. 65–78, 2009. View at Publisher · View at Google Scholar · View at Scopus
5. Z. I. Bashir, Z. A. Bortolotto, C. H. Davies et al., “Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors,” Nature, vol. 363, no. 6427, pp. 347–350, 1993. View at Publisher · View at Google Scholar · View at Scopus
6. D. G. Rainnie, K. H. Holmes, and P. Shinnick-Gallagher, “Activation of postsynaptic metabotropic glutamate receptors by trans-ACPD hyperpolarizes neurons of the basolateral amygdala,” Journal of Neuroscience, vol. 14, part 2, no. 11, pp. 7208–7220, 1994. View at Google Scholar · View at Scopus
7. W. Löscher, H. Lehmann, B. Behl, and et al, “A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy,” European Journal of Neuroscience, vol. 11, no. 1, pp. 250–262, 1999. View at Publisher · View at Google Scholar · View at Scopus
8. D. G. Trist, “Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications,” Pharmaceutica Acta Helvetiae, vol. 74, no. 2-3, pp. 221–229, 2000. View at Publisher · View at Google Scholar · View at Scopus
9. G. Sperk, “Kainic acid seizures in the rat,” Progress in Neurobiology, vol. 42, no. 1, pp. 1–32, 1994. View at Publisher · View at Google Scholar · View at Scopus
10. D.-H. Youn and M. Randić, “Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit,” Journal of Physiology, vol. 555, no. 3, pp. 683–698, 2004. View at Publisher · View at Google Scholar · View at Scopus
11. S. L. Campbell, S. S. Mathew, and J. J. Hablitz, “Pre- and postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortex,” Neuropharmacology, vol. 53, no. 1, pp. 37–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
12. E. W. Lothman and R. C. Collins, “Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates,” Brain Research, vol. 218, no. 1-2, pp. 299–318, 1981. View at Publisher · View at Google Scholar · View at Scopus
13. G. Sperk, H. Lassmann, H. Baran, F. Seitelberger, and O. Hornykiewicz, “Kainic acid-induced seizures: dose-relationship of behavioural neurochemical and histopathological changes,” Brain Research, vol. 338, no. 2, pp. 289–295, 1985. View at Publisher · View at Google Scholar · View at Scopus
14. X. Zhang, D. L. Gelowitz, C. T. Lai, A. A. Boulton, and P. H. Yu, “Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70,” European Journal of Neuroscience, vol. 9, no. 4, pp. 760–769, 1997. View at Publisher · View at Google Scholar · View at Scopus
15. Y. Ben-Ari, “Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy,” Neuroscience, vol. 14, no. 2, pp. 375–403, 1985. View at Publisher · View at Google Scholar · View at Scopus
16. A. Mikulecká, P. Kršek, and P. Mareš, “Nonconvulsive kainic acid-induced seizures elicit age-dependent impairment of memory for the elevated plus-maze,” Epilepsy & Behavior, vol. 1, no. 6, pp. 418–426, 2000. View at Publisher · View at Google Scholar · View at Scopus
17. P. Miltiadous, G. Kouroupi, A. Stamatakis, P. N. Koutsoudaki, R. Matsas, and F. Stylianopoulou, “Subventricular zone-derived neural stem cell grafts protect against hippocampal degeneration and restore cognitive function in the mouse following intrahippocampal kainic acid administration,” Stem Cells Translational Medicine, vol. 2, no. 3, pp. 185–198, 2013. View at Publisher · View at Google Scholar · View at Scopus
18. L.-H. Zeng, H.-D. Zhang, C.-J. Xu et al., “Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties,” Journal of Zhejiang University. Science B, vol. 14, no. 11, pp. 1004–1012, 2013. View at Publisher · View at Google Scholar · View at Scopus
19. M. J. Gayoso, C. Primo, A. Al-Majdalawi, J. M. Fernandez, M. Garrosa, and C. Iñiguez, “Brain lesions and water-maze learning deficits after systemic administration of kainic acid to adult rats,” Brain Research, vol. 653, no. 1-2, pp. 92–100, 1994. View at Publisher · View at Google Scholar · View at Scopus
20. A. Kumar, A. Prakash, and D. Pahwa, “Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat,” Brain Research Bulletin, vol. 85, no. 3-4, pp. 158–168, 2011. View at Publisher · View at Google Scholar · View at Scopus
21. C. E. Stafstrom, A. Chronopoulos, S. Thurber, J. L. Thompson, and G. L. Holmes, “Age-dependent cognitive and behavioral deficits after kainic acid seizures,” Epilepsia, vol. 34, no. 3, pp. 420–432, 1993. View at Publisher · View at Google Scholar · View at Scopus
22. M. Golechha, U. Chaudhry, J. Bhatia, D. Saluja, and D. S. Arya, “Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention,” Biological & Pharmaceutical Bulletin, vol. 34, no. 3, pp. 360–365, 2011. View at Publisher · View at Google Scholar · View at Scopus
23. M. R. Gluck, E. Jayatilleke, S. Shaw, A. J. Rowan, and V. Haroutunian, “CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy,” Epilepsy Research, vol. 39, no. 1, pp. 63–71, 2000. View at Publisher · View at Google Scholar · View at Scopus
24. A. J. Bruce and M. Baudry, “Oxygen free radicals in rat limbic structures after kainate-induced seizures,” Free Radical Biology and Medicine, vol. 18, no. 6, pp. 993–1002, 1995. View at Publisher · View at Google Scholar · View at Scopus
25. H.-C. Kim, W.-K. Jhoo, G. Bing et al., “Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms,” Brain Research, vol. 874, no. 1, pp. 15–23, 2000. View at Publisher · View at Google Scholar · View at Scopus
26. K. Xu, Y. Zhang, Y. Wang et al., “Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration,” PLoS ONE, vol. 9, no. 6, Article ID e101077, 2014. View at Publisher · View at Google Scholar · View at Scopus
27. I.-H. Cho, J. Hong, E. C. Suh et al., “Role of microglial IKKβ in kainic acid-induced hippocampal neuronal cell death,” Brain, vol. 131, no. 11, pp. 3019–3033, 2008. View at Publisher · View at Google Scholar · View at Scopus
28. J. Hong, I.-H. Cho, K. I. Kwak et al., “Microglial toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death,” The Journal of Biological Chemistry, vol. 285, no. 50, pp. 39447–39457, 2010. View at Publisher · View at Google Scholar · View at Scopus
29. Y.-W. Lin and C.-L. Hsieh, “Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 313–320, 2011. View at Publisher · View at Google Scholar · View at Scopus
30. Z. Chen, R.-S. Duan, H. C. Quezada et al., “Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 mice,” Journal of Neurobiology, vol. 62, no. 2, pp. 207–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
31. T. Ravizza, M. Rizzi, C. Perego et al., “Inflammatory response and glia activation in developing rat hippocampus after status epilepticus,” Epilepsia, vol. 46, supplement 5, pp. 113–117, 2005. View at Publisher · View at Google Scholar · View at Scopus
32. X.-M. Zhang, R.-S. Duan, Z. Chen et al., “IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12,” Experimental Neurology, vol. 205, no. 1, pp. 64–73, 2007. View at Publisher · View at Google Scholar · View at Scopus
33. M.-O. Lu, X.-M. Zhang, E. Mix et al., “TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice,” Journal of Neuroscience Research, vol. 86, no. 7, pp. 1608–1614, 2008. View at Publisher · View at Google Scholar · View at Scopus
34. A.-L. Sokka, N. Putkonen, G. Mudo et al., “Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain,” The Journal of Neuroscience, vol. 27, no. 4, pp. 901–908, 2007. View at Publisher · View at Google Scholar · View at Scopus
35. J. F. Torres-Peraza, T. Engel, R. Martín-Ibáñez et al., “Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus,” Brain, vol. 136, part 4, pp. 1161–1176, 2013. View at Publisher · View at Google Scholar · View at Scopus
36. Y.-C. Chuang, A. Y. W. Chang, J.-W. Lin, S.-P. Hsu, and S. H. H. Chan, “Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat,” Epilepsia, vol. 45, no. 10, pp. 1202–1209, 2004. View at Publisher · View at Google Scholar · View at Scopus
37. J. S. Kim, R. W. Heo, H. Kim et al., “Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death,” Journal of Neural Transmission, vol. 121, no. 10, pp. 1233–1243, 2014. View at Publisher · View at Google Scholar · View at Scopus
38. G. M. McKhann II, H. J. Wenzel, C. A. Robbins, A. A. Sosunov, and P. A. Schwartzkroin, “Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology,” Neuroscience, vol. 122, no. 2, pp. 551–561, 2003. View at Publisher · View at Google Scholar · View at Scopus
39. S. Ratté and J.-C. Lacaille, “Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsy,” Advances in Neurology, vol. 97, pp. 69–76, 2006. View at Google Scholar · View at Scopus
40. L.-H. Zeng, N. R. Rensing, and M. Wong, “The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy,” Journal of Neuroscience, vol. 29, no. 21, pp. 6964–6972, 2009. View at Publisher · View at Google Scholar · View at Scopus
41. S. J. Royle, F. C. Collins, H. Rupniak, J. C. Barnes, and R. Anderson, “Behavioural analysis and susceptibility to CNS injury of four inbred strains of mice,” Brain Research, vol. 816, no. 2, pp. 337–349, 1999. View at Publisher · View at Google Scholar
42. Y. Ben-Ari and R. Cossart, “Kainate, a double agent that generates seizures: two decades of progress,” Trends in Neurosciences, vol. 23, no. 11, pp. 580–587, 2000. View at Publisher · View at Google Scholar · View at Scopus
43. N. Nakao, E. M. Grasbon-Frodl, H. Widner, and P. Brundin, “Antioxidant treatment protects striatal neurons against excitotoxic insults,” Neuroscience, vol. 73, no. 1, pp. 185–200, 1996. View at Publisher · View at Google Scholar · View at Scopus
44. A. Melo, L. Monteiro, R. M. F. Lima, D. M. de Oliveira, M. D. de Cerqueira, and R. S. El-Bachá, “Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives,” Oxidative Medicine and Cellular Longevity, vol. 2011, Article ID 467180, 14 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
45. R. A. Floyd, “Antioxidants, oxidative stress, and degenerative neurological disorders,” Proceedings of the Society for Experimental Biology and Medicine, vol. 222, no. 3, pp. 236–245, 1999. View at Publisher · View at Google Scholar · View at Scopus
46. Q. Wang, S. Yu, A. Simonyi, G. Y. Sun, and A. Y. Sun, “Kainic acid-mediated excitotoxicity as a model for neurodegeneration,” Molecular Neurobiology, vol. 31, no. 1–3, pp. 3–16, 2005. View at Publisher · View at Google Scholar · View at Scopus
47. T. L. Sandhya, W. Y. Ong, L. A. Horrocks, and A. A. Farooqui, “A light and electron microscopic study of cytoplasmic phospholipase A₂ and cyclooxygenase-2 in the hippocampus after kainate lesions,” Brain Research, vol. 788, no. 1-2, pp. 223–231, 1998. View at Publisher · View at Google Scholar · View at Scopus
48. W. Y. Ong, L. J. Garey, and K. K. Tan, “An immunocytochemical study of calpain II in the hippocampus of rats injected with kainate,” Experimental Brain Research, vol. 113, no. 1, pp. 117–129, 1997. View at Publisher · View at Google Scholar · View at Scopus
49. T. C. Frank-Cannon, L. T. Alto, F. E. McAlpine, and M. G. Tansey, “Does neuroinflammation fan the flame in neurodegenerative diseases?” Molecular Neurodegeneration, vol. 4, no. 1, article 47, 2009. View at Publisher · View at Google Scholar · View at Scopus
50. W. J. Streit, R. E. Mrak, and W. S. T. Griffin, “Microglia and neuroinflammation: a pathological perspective,” Journal of Neuroinflammation, vol. 1, no. 1, article 14, 2004. View at Publisher · View at Google Scholar · View at Scopus
51. M. E. Lull and M. L. Block, “Microglial activation and chronic neurodegeneration,” Neurotherapeutics, vol. 7, no. 4, pp. 354–365, 2010. View at Publisher · View at Google Scholar · View at Scopus
52. M. L. Block and J.-S. Hong, “Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism,” Progress in Neurobiology, vol. 76, no. 2, pp. 77–98, 2005. View at Publisher · View at Google Scholar · View at Scopus
53. H.-M. Gao, H. Zhou, and J.-S. Hong, “Oxidative stress, neuroinflammation, and neurodegeneration,” in in Neuroinflammation and Neurodegeneration, P. K. Peterson and and M. Toborek, Eds., pp. 81–104, Springer, New York, NY, USA, 2014. View at Google Scholar
54. X.-Y. Zheng, H.-L. Zhang, Q. Luo, and J. Zhu, “Kainic acid-induced neurodegenerative model: potentials and limitations,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 457079, 10 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
55. X.-M. Zhang and J. Zhu, “Kainic acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines,” Current Neuropharmacology, vol. 9, no. 2, pp. 388–398, 2011. View at Publisher · View at Google Scholar · View at Scopus
56. K. L. Gilliams-Francis, A. A. Quaye, and J. R. Naegele, “PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death,” Experimental Neurology, vol. 184, no. 1, pp. 359–372, 2003. View at Publisher · View at Google Scholar · View at Scopus
57. M. V. Frantseva, J. L. P. Velazquez, P. A. Hwang, and P. L. Carlen, “Free radical production correlates with cell death in an in vitro model of epilepsy,” European Journal of Neuroscience, vol. 12, no. 4, pp. 1431–1439, 2000. View at Publisher · View at Google Scholar · View at Scopus
58. A. S. Attele, J. A. Wu, and C.-S. Yuan, “Ginseng pharmacology: multiple constituents and multiple actions,” Biochemical Pharmacology, vol. 58, no. 11, pp. 1685–1693, 1999. View at Publisher · View at Google Scholar · View at Scopus
59. M. A. Kuhn and W. David, Herbal Therapy and Supplements: A Scientific and Traditional Approach, Lippincott Williams and Wilkins, New York, NY, USA, 2000.
60. X.-Y. Lian, Z.-Z. Zhang, and J. L. Stringer, “Anticonvulsant activity of ginseng on seizures induced by chemical convulsants,” Epilepsia, vol. 46, no. 1, pp. 15–22, 2005. View at Publisher · View at Google Scholar · View at Scopus
61. S.-Y. Nah, D.-H. Kim, and H. Rhim, “Ginsenosides: are any of them candidates for drugs acting on the central nervous system?” CNS Drug Reviews, vol. 13, no. 4, pp. 381–404, 2007. View at Publisher · View at Google Scholar · View at Scopus
62. E. Tachikawa, K. Kudo, K. Harada et al., “Effects of ginseng saponins on responses induced by various receptor stimuli,” European Journal of Pharmacology, vol. 369, no. 1, pp. 23–32, 1999. View at Publisher · View at Google Scholar · View at Scopus
63. D. Tsang, H. W. Yeung, W. W. Tso, and H. Peck, “Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes,” Planta Medica, vol. 3, pp. 221–224, 1985. View at Google Scholar · View at Scopus
64. J.-H. Lee, S.-R. Kim, C.-S. Bae, D. Kim, H.-N. Hong, and S.-Y. Nah, “Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus,” Neuroscience Letters, vol. 325, no. 2, pp. 129–133, 2002. View at Publisher · View at Google Scholar · View at Scopus
65. E.-J. Shin, J. H. Jeong, A.-Y. Kim et al., “Protection against kainate neurotoxicity by ginsenosides: attenuation of convulsive behavior, mitochondrial dysfunction, and oxidative stress,” Journal of Neuroscience Research, vol. 87, no. 3, pp. 710–722, 2009. View at Publisher · View at Google Scholar · View at Scopus
66. J.-Y. Han, S.-Y. Ahn, E.-H. Oh et al., “Red ginseng extract attenuates kainate-induced excitotoxicity by antioxidative effects,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 479016, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
67. J.-S. Shi, J.-X. Yu, X.-P. Chen, and R.-X. Xu, “Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline,” Acta Pharmacologica Sinica, vol. 24, no. 2, pp. 97–101, 2003. View at Google Scholar · View at Scopus
68. Y.-F. Xian, Z.-X. Lin, Q.-Q. Mao et al., “Bioassay-guided isolation of neuroprotective compounds from Uncaria rhynchophylla against beta-amyloid-induced neurotoxicity,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 802625, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
69. T.-H. Kang, Y. Murakami, K. Matsumoto et al., “Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes,” European Journal of Pharmacology, vol. 455, no. 1, pp. 27–34, 2002. View at Publisher · View at Google Scholar · View at Scopus
70. C.-L. Hsieh, N.-Y. Tang, S.-Y. Chiang, C.-T. Hsieh, and J.-G. Lin, “Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (Miq) Jack and Gastrodia elata Bl., in kainic acid-treated rats,” Life Sciences, vol. 65, no. 20, pp. 2071–2082, 1999. View at Publisher · View at Google Scholar · View at Scopus
71. C.-L. Hsieh, M.-F. Chen, T.-C. Li et al., “Anticonvulsant effect of Uncaria rhynchophylla (Miq) Jack. in rats with kainic acid-induced epileptic seizure,” The American Journal of Chinese Medicine, vol. 27, no. 2, pp. 257–264, 1999. View at Publisher · View at Google Scholar · View at Scopus
72. C.-L. Hsieh, C.-H. Liu, Y.-W. Lin, N.-Y. Tang, and H.-J. Liu, “Neuroprotective effect of Uncaria rhynchophylla in Kainic acid-induced epileptic seizures by modulating hippocampal mossy fiber sprouting, neuron survival, astrocyte proliferation, and S100b expression,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 194790, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
73. N.-Y. Tang, C.-H. Liu, S.-Y. Su et al., “Uncaria rhynchophylla (Miq) Jack plays a role in neuronal protection in kainic acid-treated rats,” American Journal of Chinese Medicine, vol. 38, no. 2, pp. 251–263, 2010. View at Publisher · View at Google Scholar · View at Scopus
74. H.-L. Huang, C.-C. Lin, K.-C. G. Jeng et al., “Fresh green tea and gallic acid ameliorate oxidative stress in kainic acid-induced status epilepticus,” Journal of Agricultural and Food Chemistry, vol. 60, no. 9, pp. 2328–2336, 2012. View at Publisher · View at Google Scholar · View at Scopus
75. C.-W. Hou, “Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus,” Journal of Biomedical Science, vol. 18, article 75, 2011. View at Publisher · View at Google Scholar · View at Scopus
76. É. W. Teixeira, D. Message, G. Negri, A. Salatino, and P. C. Stringheta, “Seasonal variation, chemical composition and antioxidant activity of brazilian propolis samples,” Evidence-Based Complementary and Alternative Medicine, vol. 7, no. 3, pp. 307–315, 2010. View at Publisher · View at Google Scholar · View at Scopus
77. L. Wang, S. Mineshita, and I. Ga, “Antiinflamatory effects of propolis,” Japanese Journal of Pharmacological Therapeutics, vol. 24, pp. 223–226, 1993. View at Google Scholar
78. P. Basnet, T. Matsuno, and R. Neidlein, “Potent free radical scavenging activity of propol isolated from Brazilian propolis,” Zeitschrift fur Naturforschung C, vol. 52, no. 11-12, pp. 828–833, 1997. View at Google Scholar · View at Scopus
79. M. I. Isla, M. I. Nieva Moreno, A. R. Sampietro, and M. A. Vattuone, “Antioxidant activity of Argentine propolis extracts,” Journal of Ethnopharmacology, vol. 76, no. 2, pp. 165–170, 2001. View at Publisher · View at Google Scholar · View at Scopus
80. K. Natarajan, S. Singh, T. R. Burke Jr., D. Grunberger, and B. B. Aggarwal, “Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 17, pp. 9090–9095, 1996. View at Publisher · View at Google Scholar · View at Scopus
81. G. Coneac, E. Gafiţanu, D. Hădărugă et al., “Flavonoid contents of propolis from the West Side of Romania and correlation with the antioxidant activity,” Chemical Bulletin “Politehnica” University Timişoara, vol. 53, no. 67, p. 5, 2008. View at Google Scholar
82. F. Borrelli, P. Maffia, L. Pinto et al., “Phytochemical compounds involved in the anti-inflammatory effect of propolis extract,” Fitoterapia, vol. 73, supplement 1, pp. S53–S63, 2002. View at Publisher · View at Google Scholar · View at Scopus
83. A. Russo, R. Longo, and A. Vanella, “Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin,” Fitoterapia, vol. 73, supplement 1, pp. S21–S29, 2002. View at Publisher · View at Google Scholar · View at Scopus
84. M. Swamy, D. Suhaili, K. N. S. Sirajudeen, Z. Mustapha, and C. Govindasamy, “Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 11, no. 5, pp. 48–53, 2014. View at Publisher · View at Google Scholar · View at Scopus
85. Y.-S. Kwon, D.-H. Park, E.-J. Shin et al., “Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A₁ receptor modulation in the rat,” Neuroscience Letters, vol. 355, no. 3, pp. 231–235, 2004. View at Publisher · View at Google Scholar · View at Scopus
86. M. Swamy, W. Norlina, W. Azman et al., “Restoration of glutamine synthetase activity, nitric oxide levels and amelioration of oxidative stress by propolis in kainic acid mediated excitotoxicity,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 11, no. 2, pp. 458–463, 2014. View at Google Scholar
87. H. Manev, T. Uz, and T. Qu, “5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus: early response to glutamate receptor activation by kainate,” Experimental Gerontology, vol. 35, no. 9-10, pp. 1201–1209, 2000. View at Publisher · View at Google Scholar · View at Scopus
88. E. J. Kim, J. E. Lee, K. J. Kwon, S. H. Lee, C.-H. Moon, and E. J. Baik, “Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E2 production and neurodegeneration in cortical and hippocampal cell cultures,” Brain Research, vol. 908, no. 1, pp. 1–9, 2001. View at Publisher · View at Google Scholar · View at Scopus
89. H. Baran, K. Vass, H. Lassmann, and O. Hornykiewicz, “The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity,” Brain Research, vol. 646, no. 2, pp. 201–206, 1994. View at Publisher · View at Google Scholar · View at Scopus
90. L. Minutoli, H. Marini, M. Rinaldi et al., “A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury,” NeuroMolecular Medicine, vol. 17, no. 2, pp. 192–201, 2015. View at Publisher · View at Google Scholar
91. O. L. Gobbo and S. M. O'Mara, “Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration,” Neuroscience, vol. 125, no. 2, pp. 317–327, 2004. View at Publisher · View at Google Scholar · View at Scopus
92. J. W. Phillis, L. A. Horrocks, and A. A. Farooqui, “Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders,” Brain Research Reviews, vol. 52, no. 2, pp. 201–243, 2006. View at Publisher · View at Google Scholar · View at Scopus
93. M. Oprica, C. Eriksson, and M. Schultzberg, “Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system,” Journal of Cellular and Molecular Medicine, vol. 7, no. 2, pp. 127–140, 2003. View at Publisher · View at Google Scholar · View at Scopus
94. B. Shukitt-Hale, F. C. Lau, A. N. Carey et al., “Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus,” Nutritional Neuroscience, vol. 11, no. 4, pp. 172–182, 2008. View at Publisher · View at Google Scholar · View at Scopus
95. M. Bishnoi, C. S. Patil, A. Kumar, and S. K. Kulkarni, “Co-administration of acetyl-11-keto-β-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice,” Pharmacology, vol. 79, no. 1, pp. 34–41, 2007. View at Publisher · View at Google Scholar · View at Scopus
96. D.-E. Sok, S. H. Oh, Y.-B. Kim, and M. R. Kim, “Neuroprotective effect of rough aster butanol fraction against oxidative stress in the brain of mice challenged with kainic acid,” Journal of Agricultural and Food Chemistry, vol. 51, no. 16, pp. 4570–4575, 2003. View at Publisher · View at Google Scholar · View at Scopus
97. E. J. Kim, R. Won, J.-H. Sohn et al., “Anti-oxidant effect of ascorbic and dehydroascorbic acids in hippocampal slice culture,” Biochemical and Biophysical Research Communications, vol. 366, no. 1, pp. 8–14, 2008. View at Publisher · View at Google Scholar · View at Scopus
98. H.-C. Kim, W.-K. Jhoo, W.-K. Kim et al., “An immunocytochemical study of mitochondrial manganese-superoxide dismutase in the rat hippocampus after kainate administration,” Neuroscience Letters, vol. 281, no. 1, pp. 65–68, 2000. View at Publisher · View at Google Scholar · View at Scopus
99. T. B. Mojarad and M. Roghani, “The anticonvulsant and antioxidant effects of berberine in kainate-induced temporal lobe epilepsy in rats,” Basic and Clinical Neuroscience, vol. 5, no. 2, pp. 124–130, 2014. View at Google Scholar · View at Scopus
100. E.-J. Shin, K. H. Ko, W.-K. Kim et al., “Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats,” Neurochemistry International, vol. 52, no. 6, pp. 1134–1147, 2008. View at Publisher · View at Google Scholar · View at Scopus
101. M. Floreani, S. D. Skaper, L. Facci, M. Lipartiti, and P. Giusti, “Melatonin maintains glutathione homeostasis in kainic acid-exposed rat brain tissues,” The FASEB Journal, vol. 11, no. 14, pp. 1309–1315, 1997. View at Google Scholar · View at Scopus
102. E.-J. Shin, J. H. Jeong, G. Bing et al., “Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice,” Cellular Signalling, vol. 20, no. 4, pp. 645–658, 2008. View at Publisher · View at Google Scholar · View at Scopus
103. J.-K. Lee, J.-S. Won, A. K. Singh, and I. Singh, “Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death,” Neuroscience Letters, vol. 440, no. 3, pp. 260–264, 2008. View at Publisher · View at Google Scholar · View at Scopus
104. H.-C. Hsu, N.-Y. Tang, C.-H. Liu, and C.-L. Hsieh, “Antiepileptic effect of Uncaria rhynchophylla and Rhynchophylline involved in the initiation of c-jun N-terminal kinase phosphorylation of MAPK signal pathways in acute seizures of kainic acid-treated rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 961289, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
105. T.-T. Tzeng, H.-J. Tsay, L. Chang et al., “Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid,” Journal of Biomedical Science, vol. 20, no. 1, article 90, 2013. View at Publisher · View at Google Scholar · View at Scopus
106. J. Sun, C. Xie, W. Liu et al., “The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats,” International Journal of Molecular Medicine, vol. 30, no. 4, pp. 739–746, 2012. View at Publisher · View at Google Scholar · View at Scopus
107. A. Kondratyev and K. Gale, “Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus,” Molecular Brain Research, vol. 75, no. 2, pp. 216–224, 2000. View at Publisher · View at Google Scholar · View at Scopus
108. J.-K. Lee, J. W. Jeong, T. Jang et al., “Decursin attenuates kainic acid-induced seizures in mice,” NeuroReport, vol. 25, no. 16, pp. 1243–1249, 2014. View at Publisher · View at Google Scholar · View at Scopus
109. J.-K. Lee, S.-S. Choi, H.-K. Lee, K.-J. Han, E.-J. Han, and H.-W. Suh, “Effects of ginsenoside Rd and decursinol on the neurotoxic responses induced by kainic acid in mice,” Planta Medica, vol. 69, no. 3, pp. 230–234, 2003. View at Publisher · View at Google Scholar · View at Scopus
110. H. J. Shin, J. Y. Lee, E. Son et al., “Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice,” Neuroscience Letters, vol. 416, no. 1, pp. 49–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
111. I. Ullah, H. Y. Park, and M. O. Kim, “Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons,” CNS Neuroscience and Therapeutics, vol. 20, no. 4, pp. 327–338, 2014. View at Publisher · View at Google Scholar · View at Scopus
112. K. A. Lehtimäki, J. Peltola, E. Koskikallio, T. Keränen, and J. Honkaniemi, “Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures,” Molecular Brain Research, vol. 110, no. 2, pp. 253–260, 2003. View at Publisher · View at Google Scholar · View at Scopus
113. K.-J. Jang, K.-H. Lee, S.-L. Kim et al., “Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse,” Archives of Pharmacal Research, vol. 20, no. 4, pp. 375–378, 1997. View at Publisher · View at Google Scholar · View at Scopus
114. Y. Sun, S. Yin, S. Li et al., “Effects of L-arginine on seizure behavior and expression of GFAP in kainic acid-treated rats,” Neurophysiology, vol. 45, no. 1, pp. 21–25, 2013. View at Publisher · View at Google Scholar · View at Scopus
115. I. Milenkovic, N. Nedeljkovic, R. Filipovic, S. Pekovic, L. Rakic, and M. Stojiljkovic, “Pattern of glial fibrillary acidic protein expression following kainate-induced cerebellar lesion in rats,” Neurochemical Research, vol. 30, no. 2, pp. 207–213, 2005. View at Publisher · View at Google Scholar · View at Scopus
116. A. Kanada, Y. Nishimura, J.-Y. Yamaguchi et al., “Extract of Ginkgo biloba leaves attenuates kainate-induced increase in intracellular Ca²⁺ concentration of rat cerebellar granule neurons,” Biological and Pharmaceutical Bulletin, vol. 28, no. 5, pp. 934–936, 2005. View at Publisher · View at Google Scholar · View at Scopus
117. A. A. Farooqui, M. L. Litsky, T. Farooqui, and L. A. Horrocks, “Inhibitors of intracellular phospholipase A₂ activity: their neurochemical effects and therapeutical importance for neurological disorders,” Brain Research Bulletin, vol. 49, no. 3, pp. 139–153, 1999. View at Publisher · View at Google Scholar · View at Scopus
118. Y.-P. Sun, C.-K. Sun, M. Fan, D.-Y. Han, J. Zhao, and D.-Z. Gong, “Effect of no mediator on kainic acid induced behavioral seizures in rats,” Chinese Journal of Applied Physiology, vol. 19, no. 2, pp. 185–188, 2003. View at Google Scholar · View at Scopus
119. M. S. Parihar and T. Hemnani, “Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus,” Journal of Neural Transmission, vol. 111, no. 1, pp. 1–12, 2004. View at Publisher · View at Google Scholar · View at Scopus
120. S. H. Oh, D.-E. Sok, and M. R. Kim, “Neuroprotective effects of butterbur and rough aster against kainic Acid-induced oxidative stress in mice,” Journal of Medicinal Food, vol. 8, no. 2, pp. 169–176, 2005. View at Publisher · View at Google Scholar · View at Scopus
121. T.-H. Lee, J.-G. Lee, J.-M. Yon et al., “Capsaicin prevents kainic acid-induced epileptogenesis in mice,” Neurochemistry International, vol. 58, no. 6, pp. 634–640, 2011. View at Publisher · View at Google Scholar · View at Scopus
122. J.-Y. Han, S.-Y. Ahn, C.-S. Kim et al., “Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects,” Biological & Pharmaceutical Bulletin, vol. 35, no. 9, pp. 1440–1446, 2012. View at Publisher · View at Google Scholar · View at Scopus
123. Y. K. Gupta, S. Briyal, and M. Sharma, “Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats,” Indian Journal of Physiology and Pharmacology, vol. 53, no. 1, pp. 39–46, 2009. View at Google Scholar · View at Scopus
124. Y.-H. Shih, Y.-C. Chein, J.-Y. Wang, and Y.-S. Fu, “Ursolic acid protects hippocampal neurons against kainate-induced excitotoxicity in rats,” Neuroscience Letters, vol. 362, no. 2, pp. 136–140, 2004. View at Publisher · View at Google Scholar · View at Scopus
125. H.-J. Kim, K.-D. Moon, S.-Y. Oh, S.-P. Kim, and S.-R. Lee, “Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus,” Neuroscience Letters, vol. 314, no. 1-2, pp. 65–68, 2001. View at Publisher · View at Google Scholar · View at Scopus
126. Y. K. Gupta and S. Briyal, “Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats,” European Neuropsychopharmacology, vol. 16, no. 2, pp. 85–91, 2006. View at Publisher · View at Google Scholar · View at Scopus
127. S. H. Oh, T. H. Sung, and M. R. Kim, “Ixeris dentata extract maintains glutathione concentrations in mouse brain tissue under oxidative stress induced by kainic acid,” Journal of Medicinal Food, vol. 6, no. 4, pp. 353–358, 2003. View at Publisher · View at Google Scholar · View at Scopus
128. D.-E. Sok, S. H. Oh, Y.-B. Kim, H.-G. Kang, and M. R. Kim, “Neuroprotection by extract of Petasites japonicus leaves, a traditional vegetable, against oxidative stress in brain of mice challenged with kainic acid,” European Journal of Nutrition, vol. 45, no. 2, pp. 61–69, 2006. View at Publisher · View at Google Scholar · View at Scopus
129. H. S. Cui, M. R. Kim, and D.-E. Sok, “Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid,” Journal of Agricultural and Food Chemistry, vol. 53, no. 22, pp. 8526–8532, 2005. View at Publisher · View at Google Scholar · View at Scopus
130. Q. Wang, S. Yu, A. Simonyi, G. Rottinghaus, G. Y. Sun, and A. Y. Sun, “Resveratrol protects against neurotoxicity induced by kainic acid,” Neurochemical Research, vol. 29, no. 11, pp. 2105–2112, 2004. View at Publisher · View at Google Scholar · View at Scopus
131. Y. K. Gupta, S. Briyal, and G. Chaudhary, “Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats,” Pharmacology Biochemistry & Behavior, vol. 71, no. 1-2, pp. 245–249, 2002. View at Publisher · View at Google Scholar · View at Scopus
132. P. F. Hsieh, C.-W. Hou, P.-W. Yao et al., “Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation,” Journal of Neuroinflammation, vol. 8, article 57, 2011. View at Publisher · View at Google Scholar · View at Scopus
133. C.-K. Wang, L.-G. Chen, C.-L. Wen et al., “Neuroprotective activity of vitis thunbergii var. taiwaniana extracts in vitro and in vivo,” Journal of Medicinal Food, vol. 13, no. 1, pp. 170–178, 2010. View at Publisher · View at Google Scholar · View at Scopus
134. M. S. Parihar and T. Hemnani, “Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity,” Journal of Biosciences, vol. 28, no. 1, pp. 121–128, 2003. View at Publisher · View at Google Scholar · View at Scopus
135. K. S. Kang, Y. Wen, N. Yamabe, M. Fukui, S. C. Bishop, and B. T. Zhu, “Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies,” PLoS ONE, vol. 5, no. 8, Article ID e11951, 2010. View at Publisher · View at Google Scholar · View at Scopus
136. L. Luo, Y. Jin, I. Kim, and J. Lee, “Glycyrrhizin attenuates kainic Acid-induced neuronal cell death in the mouse hippocampus,” Experimental Neurobiology, vol. 22, no. 2, pp. 107–115, 2013. View at Publisher · View at Google Scholar
137. L.-Q. Ouyang, R.-S. Liang, W. Yang et al., “Effects of baicalin on the expression of IL-1beta; and TNF- and alpha; in the hippocampus of kainate-induced epileptic mice,” Journal of International Neurology and Neurosurgery, vol. 39, no. 1, pp. 16–19, 2012. View at Google Scholar
138. K. B. Duffy, E. L. Spangler, B. D. Devan et al., “A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats,” Neurobiology of Aging, vol. 29, no. 11, pp. 1680–1689, 2008. View at Publisher · View at Google Scholar · View at Scopus
139. D. H. Kim, B. H. Yoon, W. Y. Jung et al., “Sinapic acid attenuates kainic acid-induced hippocampal neuronal damage in mice,” Neuropharmacology, vol. 59, no. 1-2, pp. 20–30, 2010. View at Publisher · View at Google Scholar · View at Scopus
140. P. N'Gouemo, M. Baldy-Moulinier, and C. Nguemby-Bina, “Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents,” Journal of Ethnopharmacology, vol. 52, no. 2, pp. 77–83, 1996. View at Publisher · View at Google Scholar · View at Scopus
141. T.-Y. Lin, W.-J. Huang, C.-C. Wu, C.-W. Lu, and S.-J. Wang, “Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats,” PLoS ONE, vol. 9, no. 2, Article ID e88644, 2014. View at Publisher · View at Google Scholar · View at Scopus
142. J.-S. Byun, Y. H. Han, S.-J. Hong et al., “Bark constituents from mushroom-detoxified Rhus verniciflua suppress kainic acid-induced neuronal cell death in mouse hippocampus,” Korean Journal of Physiology and Pharmacology, vol. 14, no. 5, pp. 279–283, 2010. View at Publisher · View at Google Scholar · View at Scopus