Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 973930, 12 pages
http://dx.doi.org/10.1155/2015/973930
Research Article

Serum Pharmacochemistry Analysis Using UPLC-Q-TOF/MS after Oral Administration to Rats of Shenfu Decoction

1Graduate School, Anhui Medical University, Hefei, China
2Beijing Institute of Radiation Medicine, Tai-Ping Road 27, Beijing 100850, China

Received 23 October 2014; Revised 27 May 2015; Accepted 28 May 2015

Academic Editor: Kazuo Toda

Copyright © 2015 Jia-le He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-H. Chen, C.-Y. Lee, B.-C. Liau, M.-R. Lee, T.-T. Jong, and S.-T. Chiang, “Determination of aconitine-type alkaloids as markers in fuzi (Aconitum carmichaeli) by LC/(+)ESI/MS3,” Journal of Pharmaceutical and Biomedical Analysis, vol. 48, no. 4, pp. 1105–1111, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. Z.-J. Guo and C.-S. Li, “Therapeutic effects of shenfu injection on post-cardiac arrest syndrome,” Chinese Journal of Integrative Medicine, vol. 19, no. 9, pp. 716–720, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Luo, S. Min, K. Wei, and J. Cao, “Ion channel mechanism and ingredient bases of Shenfu Decoction's cardiac electrophysiological effects,” Journal of Ethnopharmacology, vol. 117, no. 3, pp. 439–445, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. X. J. Wang, “Studies on serum pharmacochemistry of traditional Chinese medicine,” World Science and Technology, vol. 4, no. 2, pp. 1–5, 2002. View at Google Scholar
  5. S.-S. Zhou, Z.-C. Ma, Y. Gao, and et al, “UPLC-TOF/MS based chemical profiling approach to evaluate toxicity-attenuated chemical composition in combination of ginseng and Radix Aconiti Praeparata,” Acta Pharmaceutica Sinica, vol. 46, no. 12, pp. 1488–1492, 2011. View at Google Scholar · View at Scopus
  6. H. Li, Y.-G. Wang, Z.-C. Ma et al., “Effect of Shenfu injection on CYP450s of rat liver,” Acta Pharmaceutica Sinica, vol. 48, no. 5, pp. 728–733, 2013. View at Google Scholar · View at Scopus
  7. Y.-G. Wang, H.-S. Liu, Y. Gao et al., “Screening of pregnane X receptor activation from ginsenosides,” Acta Pharmaceutica Sinica, vol. 48, no. 1, pp. 144–148, 2013. View at Google Scholar · View at Scopus
  8. S. S. Zhou, Z. C. Ma, Q. Liang et al., “UPLC/Q-TOF-MS based chemical profiling approach to evaluate chemical composition of augmentation toxicity in combination of radix aconiti and pinellia praeparata,” Acta Chimica Sinica, vol. 70, no. 3, pp. 284–290, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. S. Zhou, Z. C. Ma, Y. Gao et al., “UPLC/Q-TOF-MS based chemical profiling approach to evaluate ginsenoside composition in combination of ginseng and radix ophiopogonis,” Journal of Chinese Mass Spectrometry Society, vol. 34, no. 2, pp. 88–91, 2013. View at Google Scholar
  10. J.-L. He, S.-S. Zhou, Z.-C. Ma et al., “To evaluate the meterial basis of Shenfu injection based on UPLC-Q-TOF/MS,” Chinese Pharmacological Bulletin, vol. 30, no. 3, pp. 429–433, 2014. View at Google Scholar · View at Scopus
  11. L. Ye, X. S. Yang, Z. Q. Yang et al., “The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells,” Toxicology Letters, vol. 216, no. 2-3, pp. 86–99, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Li, R. Tsao, Z. G. Sui, J. Ma, Z. Lie, and Z. Lie, “Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model,” Planta Medica, vol. 78, no. 7, pp. 692–697, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Yang, Z. Li, T. Zhang, F. Liu, J. Ruan, and Z. Zhang, “Transcellular transport of aconitine across human intestinal Caco-2 cells,” Food and Chemical Toxicology, vol. 57, pp. 195–200, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Ameri, “The effects of Aconitum alkaloids on the central nervous system,” Progress in Neurobiology, vol. 56, no. 2, pp. 211–235, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. A. M. Bello-Ramírez, J. Buendía-Orozco, and A. A. Nava-Ocampo, “A QSAR analysis to explain the analgesic properties of Aconitum alkaloids,” Fundamental and Clinical Pharmacology, vol. 17, no. 5, pp. 575–580, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. P. J. Tong, C. L. Wu, X. F. Wang et al., “Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy,” Journal of Ethnopharmacology, vol. 146, no. 2, pp. 562–571, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Guo, M. T. Liu, D. W. Yang et al., “Quantitative LC-MS/MS analysis of seven ginsenosides and three aconitum alkaloids in Shen-Fu decoction,” Chemistry Central Journal, vol. 7, no. 1, article 165, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Tang, Y. Gong, C. Lv, L. Ye, L. Liu, and Z. Liu, “Pharmacokinetics of aconitine as the targeted marker of fuzi (Aconitum carmichaeli) following single and multiple oral administrations of fuzi extracts in rat by UPLC/MS/MS,” Journal of Ethnopharmacology, vol. 141, no. 2, pp. 736–741, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. J.-M. Zhang, W. Liao, Y.-X. He, Y. He, D. Yan, and C.-M. Fu, “Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from Fuzi-Gancao herb-pair decoction for its potential interaction mechanism investigation,” Journal of Ethnopharmacology, vol. 147, no. 1, pp. 128–135, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Li, R. Zhang, X. Wang, X. Hu, Y. Chen, and Q. Liu, “Simultaneous determination of seven ginsenosides in rat plasma by high-performance liquid chromatography coupled to time-of-flight mass spectrometry: application to pharmacokinetics of Shenfu injection,” Biomedical Chromatography, vol. 29, no. 2, pp. 167–175, 2015. View at Publisher · View at Google Scholar
  21. H. Yang, L. Liu, W. Gao, K. Liu, L.-W. Qi, and P. Li, “Direct and comprehensive analysis of ginsenosides and diterpene alkaloids in Shenfu injection by combinatory liquid chromatography-mass spectrometric techniques,” Journal of Pharmaceutical and Biomedical Analysis, vol. 92, pp. 13–21, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Tazawa, H.-Q. Zhao, Y. Li et al., “A new enzyme immunoassay for aconitine and its application to quantitative determination of aconitine levels in plasma,” Biological and Pharmaceutical Bulletin, vol. 26, no. 9, pp. 1289–1294, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Zhang, M.-H. Tang, L.-J. Chen et al., “Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of ‘SHEN-FU’ injectable powder,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 873, no. 2, pp. 173–179, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. C.-Z. Wang, K. E. Kim, G.-J. Du et al., “Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma,” The American Journal of Chinese Medicine, vol. 39, no. 6, pp. 1161–1171, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. C. X. Liu, Y. Z. Hou, X. L. Wang et al., “Clinical assessment of Shenfu injection loading in the treatment of patients with exacerbation of chronic heart failure due to coronary heart disease: study protocol for a randomized controlled trial,” Trials, vol. 16, no. 1, article 222, 2015. View at Publisher · View at Google Scholar
  26. Y. L. Zhao, J. B. Wang, X. J. Sun et al., “Microcalorimetry coupled with chemometric techniques for toxicity evaluation of Radix Aconiti Lateralis Preparata (Fuzi) and its processed products on Escherichia coli,” Applied Microbiology and Biotechnology, vol. 98, no. 1, pp. 437–444, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Ye, X.-S. Yang, L.-L. Lu et al., “Monoester-diterpene aconitum alkaloid metabolism in human liver microsomes: predominant role of CYP3A4 and CYP3A5,” Evidence-based Complementary and Alternative Medicine, vol. 2013, Article ID 941093, 24 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. Q. You, Z. C. Ma, Y. G. Wang et al., “Absorption characteristics of panax ginseng water extract in Caco-2 cell monolayer,” Chinese Pharmacology Bulletin, vol. 29, no. 12, pp. 1711–1716, 2013. View at Google Scholar
  29. K. Wada, M. Nihira, H. Hayakawa, Y. Tomita, M. Hayashida, and Y. Ohno, “Effects of long-term administrations of aconitine on electrocardiogram and tissue concentrations of aconitine and its metabolites in mice,” Forensic Science International, vol. 148, no. 1, pp. 21–29, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. W.-W. Peng, W. Li, J.-S. Li et al., “The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis-Rhizoma Zingiberis,” Journal of Ethnopharmacology, vol. 148, no. 2, pp. 579–586, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Sun, W. Wu, Y. Y. Guo, Q. Qin, and S. Liu, “Pharmacokinetic study of ginsenoside Rc and simultaneous determination of its metabolites in rats using RRLC-Q-TOF-MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 88, pp. 16–21, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. F. Zhao, L. Xu, and L. Xu, “Trains of thoughts and methods in studying substantial basis of effects of Chinese medicinal compounds,” Chinese Journal of Integrated Medicine, vol. 27, no. 1, pp. 80–82, 2007. View at Google Scholar · View at Scopus