Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2016 (2016), Article ID 1230294, 10 pages
http://dx.doi.org/10.1155/2016/1230294
Research Article

Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats

1College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea
2College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea
3College of Medicine, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea
4Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea
5School of Information and Communications, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

Received 22 October 2015; Revised 22 April 2016; Accepted 24 April 2016

Academic Editor: Ke Ren

Copyright © 2016 Wangin Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. M. Porth, Essentials of Pathophysiology: Concepts of Altered Health States, Wolters Kluwer Health/Lippincott Williams & Wilkins, 3rd edition, 2011.
  2. A. J. MacGregor and A. J. Silman, “Rheumatoid arthritis and other synovial disorders: classification and epidemiology,” in Rheumatology, M. C. Hochberg, A. J. Silman, J. S. Smolen, M. E. Weinblatt, and M. H. Weisman, Eds., vol. 1, Mosby, London, UK, 2004. View at Google Scholar
  3. S. E. Gabriel and K. Michaud, “Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases,” Arthritis Research and Therapy, vol. 11, no. 3, article 229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. I. B. McInnes and G. Schett, “Cytokines in the pathogenesis of rheumatoid arthritis,” Nature Reviews Immunology, vol. 7, no. 6, pp. 429–442, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. G. S. Firestein, “Evolving concepts of rheumatoid arthritis,” Nature, vol. 423, no. 6937, pp. 356–361, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Okada, D. Wu, G. Trynka et al., “Genetics of rheumatoid arthritis contributes to biology and drug discovery,” Nature, vol. 506, no. 7488, pp. 376–381, 2014. View at Publisher · View at Google Scholar
  7. D. E. Furst and P. Emery, “Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets,” Rheumatology, vol. 53, no. 9, pp. 1560–1569, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Bresnihan, J. M. Alvaro-Gracia, M. Cobby et al., “Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist,” Arthritis and Rheumatism, vol. 41, no. 12, pp. 2196–2204, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Zhuang, S. Lyn, Y. Lv et al., “Pharmacokinetics and safety of golimumab in healthy Chinese subjects following a single subcutaneous administration in a randomized phase I trial,” Clinical Drug Investigation, vol. 33, no. 11, pp. 795–800, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. B.-R. Jeoung, K. D. Lee, C.-S. Na, Y.-E. Kim, B. Kim, and Y. R. Kim, “Ganghwaljetongyeum, an anti-arthritic remedy, attenuates synoviocyte proliferation and reduces the production of proinflammatory mediators in macrophages: the therapeutic effect of GHJTY on rheumatoid arthritis,” BMC Complementary and Alternative Medicine, vol. 13, article 47, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Choi, C. Choi, Y. R. Kim, S. Kim, C. Na, and H. Lee, “HerDing: herb recommendation system to treat diseases using genes and chemicals,” Database, vol. 2016, Article ID baw011, 2016. View at Publisher · View at Google Scholar
  12. H. W. Jung, R. Mahesh, J. H. Park, Y. C. Boo, K. M. Park, and Y.-K. Park, “Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-κB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells,” International Immunopharmacology, vol. 10, no. 2, pp. 155–162, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Lee, E. J. Shin, K. H. Son, H. W. Chang, S. S. Kang, and H. P. Kim, “Anti-inflammatory activity of the major constituents of Lonicera japonica,” Archives of Pharmacal Research, vol. 18, no. 2, pp. 133–135, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Peng, P. K. Perera, Y.-M. Li, W.-R. Fang, L.-F. Liu, and F.-W. Li, “Anti-inflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF-κB, TNF-α, and COX-2 in collagen-induced arthritis in rat,” Rheumatology International, vol. 32, no. 10, pp. 3119–3125, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. S. S. Joo, D. S. Park, S. H. Shin et al., “Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models,” Environmental Toxicology and Pharmacology, vol. 30, no. 2, pp. 127–133, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. J.-H. Kim, J.-E. Huh, Y.-H. Baek, J.-D. Lee, D.-Y. Choi, and D.-S. Park, “Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes,” Journal of Ethnopharmacology, vol. 134, no. 2, pp. 234–242, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Roubenoff, L. M. Freeman, D. E. Smith, L. W. Abad, C. A. Dinarello, and J. J. Kehayias, “Adjuvant arthritis as a model of inflammatory cachexia,” Arthritis and Rheumatism, vol. 40, no. 3, pp. 534–539, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Omoto, Y. Kawahito, I. Prudovsky et al., “Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats,” Arthritis Research & Therapy, vol. 7, no. 6, pp. R1174–R1182, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. C. M. Pearson, “Development of arthritis, periarthritis and periostitis in rats given adjuvants,” Experimental Biology and Medicine, vol. 91, no. 1, pp. 95–101, 1956. View at Publisher · View at Google Scholar
  20. M. Durai, H. R. Kim, and K. D. Moudgil, “The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis,” The Journal of Immunology, vol. 173, no. 1, pp. 181–188, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. S. S. Patel and P. V. Shah, “Evaluation of anti-inflammatory potential of the multidrug herbomineral formulation in male Wistar rats against rheumatoid arthritis,” Journal of Ayurveda and Integrative Medicine, vol. 4, no. 2, pp. 86–93, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. M. L. Andersen, E. H. R. Santos, M. D. L. V. Seabra, A. A. B. da Silva, and S. Tufik, “Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats,” Journal of Ethnopharmacology, vol. 91, no. 2-3, pp. 325–330, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Bendele, J. Mccomb, T. Gould et al., “Animal models of arthritis: relevance to human disease,” Toxicologic Pathology, vol. 27, no. 1, pp. 134–142, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. J. D. Taurog, D. C. Argentieri, and R. A. McReynolds, “Adjuvant arthritis,” Methods in Enzymology, vol. 162, pp. 339–355, 1988. View at Publisher · View at Google Scholar · View at Scopus
  25. X.-X. Zhang, Y. Ito, J.-R. Liang, J.-L. Liu, J. He, and W.-J. Sun, “Therapeutic effects of total steroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H.Wright in Freund's complete adjuvant induced arthritis in rats,” International Immunopharmacology, vol. 23, no. 2, pp. 407–416, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-F. Zhang, S.-L. Zhang, X. He et al., “Antioxidant effects of Genkwa flos flavonoids on Freund’s adjuvant-induced rheumatoid arthritis in rats,” Journal of Ethnopharmacology, vol. 153, no. 3, pp. 793–800, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. D. D. Obiri, N. Osafo, P. G. Ayande, and A. O. Antwi, “Xylopia aethiopica (Annonaceae) fruit extract suppresses Freunds adjuvant-induced arthritis in Sprague-Dawley rats,” Journal of Ethnopharmacology, vol. 152, no. 3, pp. 522–531, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Li, A.-P. Lu, Y.-Y. Wang, and Y.-D. Li, “Suppressive effects of a Chinese herbal medicine Qing-Luo-Yin extract on the angiogenesis of collagen-induced arthritis in rats,” The American Journal of Chinese Medicine, vol. 31, no. 5, pp. 713–720, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Zhang, M. Jiang, and A. Lu, “Chinese herbal medicines versus disease modifying antirheumatic drugs for management of rheumatoid arthritis: a systematic review,” European Journal of Integrative Medicine, vol. 3, no. 3, pp. e219–e231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Liu, C.-B. Huang, Y. Wang et al., “Chinese herbal medicine Xinfeng Capsule in treatment of rheumatoid arthritis: study protocol of a multicenter randomized controlled trial,” Journal of Integrative Medicine, vol. 11, no. 6, pp. 428–434, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. F. M. Brennan and I. B. McInnes, “Evidence that cytokines play a role in rheumatoid arthritis,” Journal of Clinical Investigation, vol. 118, no. 11, pp. 3537–3545, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. RefSeq, “RefSeq: NCBI Reference Sequence Database,” 2008, http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3553.
  33. S. L. Masters, A. Simon, I. Aksentijevich, and D. L. Kastner, “Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease,” Annual Review of Immunology, vol. 27, pp. 621–668, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Van Der Poll, C. V. Keogh, X. Guirao, W. A. Buurman, M. Kopf, and S. F. Lowry, “Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia,” Journal of Infectious Diseases, vol. 176, no. 2, pp. 439–444, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. M. A. Febbraio and B. K. Pedersen, “Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?” Exercise & Sport Sciences Reviews, vol. 33, no. 3, pp. 114–119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. E. H. S. Choy and G. S. Panayi, “Cytokine pathways and joint inflamation in rheumatoid arthritis,” The New England Journal of Medicine, vol. 344, no. 12, pp. 907–916, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. K. J. Tracey, “The inflammatory reflex,” Nature, vol. 420, no. 6917, pp. 853–859, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. V. A. Pavlov and K. J. Tracey, “Controlling inflammation: the cholinergic anti-inflammatory pathway,” Biochemical Society Transactions, vol. 34, no. 6, pp. 1037–1040, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. N. Sattar, D. W. McCarey, H. Capell, and I. B. McInnes, “Explaining how ‘high-grade’ systemic inflammation accelerates vascular risk in rheumatoid arthritis,” Circulation, vol. 108, no. 24, pp. 2957–2963, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. E. G. Giannini, R. Testa, and V. Savarino, “Liver enzyme alteration: a guide for clinicians,” Canadian Medical Association Journal, vol. 172, no. 3, pp. 367–379, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. C. I. B. Walker, G. Trevisan, M. F. Rossato et al., “Antinociceptive effect of Mirabilis jalapa on acute and chronic pain models in mice,” Journal of Ethnopharmacology, vol. 149, no. 3, pp. 685–693, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. A. A. Adeneye, A. I. Oreagba, I. O. Ishola, and H. A. Kalejaiye, “Evaluation of the anti-arthritic activity of the hydroethanolic leaf extract of Alchornea cordifolia in rats,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 11, no. 2, pp. 402–410, 2014. View at Publisher · View at Google Scholar