Research Article

PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats

Figure 5

Electron micrographs of myelinated fibers of sciatic nerves. Compared to control group (a), the nerves in diabetic rats of DM group (b) showed depressed axons by thickened tunica vaginalis, crenulate Schwann cells with higher electron density, much fewer organelles, impaired basement membranes, and irregular nuclei. The ultrastructures were almost normal by Tongxinluo treatment in DM+Txl group (c). Arrows indicate Schwann cells.