Liuwei Dihuang Pills Enhance the Effect of Western Medicine in Treating Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics and methodological quality of included studies.

Reference (year)	Study design	Participants T/C	Intervention (herbs included)	Control	Outcome measure	Treatment duration (days)
Cao (2013) [18]	RCT	36/36	LDP treatment (6 g, bid) plus acarbose (100 mg, tid)	Acarbose (100 mg, tid)	24 h UTP; FBG; PBG; UmAlb	60
Lou (2014) [32]	RCT	60/60	LDP treatment (8 pills, tid) plus telmisartan (80 mg, qd) plus routine treatment	Telmisartan (80 mg, qd) plus routine treatment	24 h UTP	360
Li and Zhao (2011) [26]	RCT	30/30	LDP treatment (8 pills, tid) plus routine treatment	Routine treatment	UAER	90
He et al. (2009) [20]	RCT	17/18	LDP treatment (8 pills, tid) plus Benazepril Hydrochloride (10 mg, qd)	Benazepril Hydrochloride (10 mg, qd)	24 h UTP	90
Song et al. (2004) [28]	RCT	41/31	LDP treatment (9 g, tid) plus routine treatment	Routine treatment	FBG, PBG, UAER	90
Chen and Ling (2004) [15]	RCT	38/30	LDP treatment (6 g, tid) plus captopril (12.5 mg, tid) plus routine treatment	Captopril (12.5 mg, tid) plus routine treatment	UAER	90
Liu (2012) [21]	RCT	30/30	LDP treatment (9 g, bid) plus routine treatment	Routine treatment	BUN, Scr	60
Kong and Zeng (2014) [17]	RCT	25/25	LDP treatment (8 pills, tid) plus routine treatment	Routine treatment	FBG, PBG, HbA1c	360
Chen et al. (2009) [23]	RCT	34/34	LDP treatment (10 g, bid) plus routine treatment	Routine treatment	UAER, FBG, BUN, Scr	60
Wang (2015) [24]	RCT	50/50	LDP treatment (9 g, bid) plus Losartan Potassium (50 mg, qd)	Losartan Potassium tablets (50 mg, qd)	Scr, BUN, UmAlb, UAER	56
Wang et al. (2013) [16]	RCT	33/30	LDP treatment (6 g, bid) plus valsartan dispersible (80 mg, qd) plus routine treatment	Valsartan dispersible (80 mg, qd) plus routine treatment	UAER, UmAlb	28
Yin et al. (2010) [29]	RCT	17/17	LDP treatment (6 g, bid) plus routine treatment	Routine treatment	FBG, UmAlb	56
Li (2013) [22]	RCT	37/38	LDP treatment (8 pills, tid) plus enalapril (5 mg, bid)	Enalapril (5 mg, bid)	FBG, UmAlb, HbA1c	42
Zhong et al. (2010) [30]	RCT	21/21	LDP treatment (6 g, bid) plus routine treatment	Routine treatment	Scr	21
Zhao (2010) [25]	RCT	30/30	LDP treatment (8 pills, tid) plus routine treatment	Routine treatment	24 h UTP	90
Ma (2015) [31]	RCT	74/74	LDP treatment (8 pills, tid) plus Losartan Potassium (50 mg, qd)	Losartan Potassium tablets (50 mg, qd)	UAER, Scr, BUN	180
Deng et al. (2006) [19]	RCT	22/22	LDP treatment (10 g, tid) plus Perindopril (2 mg, qd) plus routine treatment	Perindopril (2 mg, qd) plus routine treatment	UmAlb	56
Lv and Wang (2006) [27]	RCT	45/41	LDP treatment (8 pills, tid) plus routine treatment	Routine treatment	24 h UTP, UAER, Scr	112