Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum

Figure 3

Isobolograms constructed based on the combined effect of fendiline and the antileishmanial drugs. Isobolograms generated based on FIC₅₀ (left side) and FIC₉₀ (right side) values showing the interaction between fendiline and antileishmanial standard drugs against L. (L.) infantum promastigotes. Fendiline plus amphotericin B (a and b), miltefosine (c and d), and pentamidine (e and f). The dotted line corresponds to the predicted position of the experimental points for a simple additive effect and points corresponding to the FIC values were connected by a tendency line.

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