Research Article

Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum

Figure 3

Isobolograms constructed based on the combined effect of fendiline and the antileishmanial drugs. Isobolograms generated based on FIC50 (left side) and FIC90 (right side) values showing the interaction between fendiline and antileishmanial standard drugs against L. (L.) infantum promastigotes. Fendiline plus amphotericin B (a and b), miltefosine (c and d), and pentamidine (e and f). The dotted line corresponds to the predicted position of the experimental points for a simple additive effect and points corresponding to the FIC values were connected by a tendency line.