Evidence-Based Complementary and Alternative Medicine / 2016 / Article / Tab 1

Research Article

Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum

Table 1

Effect of CCBs and standard drugs on parasites and mammalian cells.

DrugIC50 (μM) ± SD
L. (L.) infantum
promastigotes
L. (L.) infantum
amastigotes
L. (L.) amazonensis
promastigotes
L. (V.) braziliensis
promastigotes
T. cruzi
trypomastigotes
LLC-MK2
cytotoxicity

Amrinonenenenenene>500
Fendiline16.15 ± 4.2012.20 ± 1.748.66 ± 1.279.15 ± 0.7812.13 ± 2.9749.85 ± 8.16
Lidoflazine17.67 ± 0.9316.29 ± 4.4511.54 ± 1.4914.48 ± 1.0810.39 ± 1.87106.54 ± 57.99
Mibefradil3.60 ± 0.11ne2.23 ± 0.422.75 ± 0.392.99 ± 0.4311.96 ± 1.03
Pentamidine1.06 ± 0.12nd1.14 ± 0.150.69 ± 0.04nd23.48 ± 3.53
Glucantimend30.15 ± 1.18ndndnd>500
Benznidazolendndndnd440.18 ± 39.14>500

IC50: 50% inhibitory concentration ± standard deviation (SD).
ne: not effective.
nd: not determined.
Concentrations for Glucantime are expressed as µg/mL, as the molecular weight is unknown.

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