Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of<i> Leishmania (L.) infantum</i>

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Combination</td><td class="align_center"><span style="width: 55.3342ptpx;"><svg height="13.1242pt" id="M54" style="vertical-align:-3.27285pt" version="1.1" viewbox="-0.0498162 -9.85135 55.3342 13.1242" width="55.3342pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M536 404C536 423 520 448 491 448C445 448 398 404 308 283L286 338C255 416 242 448 217 448C182 448 138 402 92 341L111 321C149 368 169 378 178 378C188 378 198 363 214 320L254 212C185 117 138 65 107 65C98 65 85 69 82 75C79 82 73 86 65 86C44 86 23 60 23 39C23 7 44 -12 71 -12C119 -12 168 33 265 177L306 61C321 17 347 -12 373 -12C413 -12 465 33 507 96L491 119C459 84 432 60 413 60C395 60 378 92 358 148L321 250C341 279 369 310 389 332C417 363 439 382 456 382C466 382 475 376 481 368C486 361 492 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110C39 47 88 -12 159 -12C189 -12 237 25 277 52C282 35 288 21 301 8C312 -3 333 -12 348 -12L433 39ZM275 84C256 65 221 48 195 48C164 48 124 73 124 124C124 161 146 180 185 198C206 208 254 229 275 240V84Z" id="g190-98"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="439" vert-adv-y="439"></glyph.data></g></svg></span></td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Fendiline + amphotericin B</td><td class="align_center">1.18</td><td class="align_center">0.99</td></tr><tr><td class="align_left">Fendiline + miltefosine</td><td class="align_center">1.30</td><td class="align_center">1.02</td></tr><tr><td class="align_left">Fendiline + pentamidine</td><td class="align_center">1.22</td><td class="align_center">1.10</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><svg height="9.90116pt" id="M56" style="vertical-align:-0.04981041pt" version="1.1" viewbox="-0.0498162 -9.85135 4.60763 9.90116" width="4.60763pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 365 44 353 44 339C44 315 69 296 87 296C101 296 111 303 116 319C124 349 133 371 145 385C156 397 171 404 190 404C241 404 275 364 275 291V274C253 256 180 229 120 209C65 190 39 159 39 110C39 47 88 -12 159 -12C189 -12 237 25 277 52C282 35 288 21 301 8C312 -3 333 -12 348 -12L433 39ZM275 84C256 65 221 48 195 48C164 48 124 73 124 124C124 161 146 180 185 198C206 208 254 229 275 240V84Z" id="g190-98"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="439" vert-adv-y="439"></glyph.data></g></svg>Overall mean sum.<br/></td></tr></table>

Effect of combination of fendiline and antileishmanial standard drugs in <i>L. (L.) infantum</i> promastigotes.

Evidence-Based Complementary and Alternative Medicine

tab3

Table 3

Table 3: Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of<i> Leishmania (L.) infantum</i> 

Evidence-Based Complementary and Alternative Medicine

Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum

Table 3