Hataedock Treatment Has Preventive Therapeutic Effects in Atopic Dermatitis-Induced NC/Nga Mice under High-Fat Diet Conditions

Figure 4

The maintenance of lipid barrier in epidermis. The LXR-positive reaction (arrow indicates dark brown) in HDE remarkably decreased but was maintained in HTT (LXR immunohistochemistry; bar size, 50 μm). The intercellular lipid lamellae (arrow indicates reddish line) of the stratum corneum disappeared in HDE but appeared in HTT (oil red O; bar size, 50 μm). The PKC-positive reaction (arrow indicates dark brown) in HTT remarkably decreased (PKC immunohistochemistry; bar size, 50 μm). Data of LXR and PKC image analysis was also showing the same result (). Ctrl: normal feeding, HF: high-fat diet, HDE: high-fat diet and untreated AD-induced, HTT: high fat diet and Hataedock treated AD-induced, EP: epidermis, DE: dermis, SC: stratum corneum, SG: stratum granulosum, SB: stratum basale, LXR: liver X receptor, and PKC: protein kinase C. , compared with the Ctrl group; , compared with the HF group; , compared with the HDE group.