Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats

<div>Experimental protocol diagram. One week after surgery, rats received dura electrical stimulation every 2 days from day 1 to day 5 (days 1, 3, and 5). EA pretreatment was performed every day on both dura stimulation period (before dura electrical stimulation) and blank period (days 0, 2, and 4) in EA group. Spontaneous homecage behaviors recording by HomeCageScan was assessed immediately after dura electrical stimulation (days 1, 3, and 5). Plasma 5-HT immunoreactivity and central 5-HT HPLC determination were performed on day 5.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats 

Figure 1 | Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats 