Figure 10: The schematic diagram illustrates the possible neuroprotective pathways of B401 treatment in the brain tissue of 3× Tg-AD mice. 3× Tg-AD mice under oral herbal formula B401 treatment enhance neuroprotection via increasing expression levels of BDNF, VEGF, and antioxidative SOD2 and alleviate neurodegeneration via suppressing ROS production, decreasing expression levels of Aβ, p-Tau, NFTs, and oxidation-related 3-NT. Taking these effects, the herbal formula B401 may alleviate cognitive deficits in 3× Tg-AD mice.