Evidence-Based Complementary and Alternative Medicine / 2016 / Article / Fig 10

Research Article

Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease

Figure 10

The schematic diagram illustrates the possible neuroprotective pathways of B401 treatment in the brain tissue of 3× Tg-AD mice. 3× Tg-AD mice under oral herbal formula B401 treatment enhance neuroprotection via increasing expression levels of BDNF, VEGF, and antioxidative SOD2 and alleviate neurodegeneration via suppressing ROS production, decreasing expression levels of Aβ, p-Tau, NFTs, and oxidation-related 3-NT. Taking these effects, the herbal formula B401 may alleviate cognitive deficits in 3× Tg-AD mice.