Membrane Stabilization and Detoxification of Acetaminophen-Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction of Zea mays L. (Poaceae), Stigma maydis
Table 2
Effect of Zea mays, Stigma maydis ethyl acetate fraction on the body weight changes and relative organ weights of acetaminophen-treated rats (, mean ± SEM).
Treatments
Weight changes
Kidney weight (g)
RKW (g/100 g b.w.)
Initial (g)
Final (g)
% weight gain
Sterile placebo (control)
210.22 ± 0.90
224.01 ± 0.89
6.16
1.61 ± 0.01
0.72
APAP treatment
220.12 ± 0.77
215.00 ± 0.99
(2.34)
0.97 ± 0.01
0.45
200 mg/kg b.w. CSEAF
200.05 ± 0.54
220.01 ± 0.86
9.07
1.69 ± 0.01
0.77
100 mg/kg b.w. CSEAF, then APAP
212.21 ± 0.75
223.09 ± 0.76
4.88
1.58 ± 0.02
0.71
200 mg/kg b.w. CSEAF, then APAP
206.15 ± 0.45
227.31 ± 0.69
9.31
1.73 ± 0.01
0.76
200 mg/kg b.w. vitamin C, then APAP
215.05 ± 0.39
228.19 ± 0.50
5.76
1.64 ± 0.02
0.72
APAP, then 100 mg/kg b.w. CSEAF
200.15 ± 0.31
205.99 ± 0.56
2.84
1.49 ± 0.02
0.73
APAP, then 200 mg/kg b.w. CSEAF
219.02 ± 0.97
232.00 ± 0.67
5.60
1.72 ± 0.01
0.74
APAP, then 200 mg/kg b.w. vitamin C
221.09 ± 0.75
227.23 ± 0.45
2.70
1.63 ± 0.01
0.72
Values bearing different superscripts along the same column for each parameter are significantly different (). Parenthesis signifies reduced value for the parameter. RKW: relative kidney-body weight.
