Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats

Figure 3

Gross evaluation of the esophageal mucosal damage. (a) Representative microphotographs of the esophagus. Esophageal lesion observed in rats with induced reflux esophagitis (RE) was ameliorated by RC-mix (100, 200, and 400 mg/kg body weight/day, p.o.) administration. (b) Gross mucosal injury ratio at the end of experiment. The gross mucosal injury was increased in RE rats compared with normal rats, but RC-mix administration led to a significant decrease (RC200, ; RC400, ). N, normal rats; Veh, positive control rats with reflux esophagitis (RE); RC100, RC200, and RC400 RE rats, animals treated with RC-mix 100 mg/kg, RC-mix 200 mg/kg, and RC-mix 400 mg/kg body weight, respectively. Data are the means ± SEM. Significance: , , and versus RE control rat values. in each group.

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