Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes

Figure 2

Hierarchical clustering analysis of TCM classes and subclasses is based on the similarity of the bioactivity fingerprint of each class. The “Tranquil-settle” subclass was not included here (and in the further analysis) since it only contained a single compound for which no reliable targets could be predicted. The (sub)classes were defined into 14 clusters, where clusters VII, X, and XII were selected for further analysis based on the top three enriched targets/pathways.