Evidence-Based Complementary and Alternative Medicine

Research Article

Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes

Table 5

The top three enriched pathways in clusters VII, X, and XII. It can be seen that, in many cases, similar pathways appear in the top three enriched targets regardless of clusters and subclasses. Estimation Score = 0, for all top three enriched pathways.


	TCM therapeutic action class	TCM therapeutic action subclass	Top three enriched pathways	Average Score

Cluster X	Wind-dampness dispelling	Bone (sinew) strengthening	hsa04978, mineral absorption	0.0342
			hsa04973, carbohydrate digestion and absorption	0.1427
			hsa04976, bile secretion	0.2050
	Tonifying and replenishing	Qi tonifying	hsa04978, mineral absorption	0.0321
			hsa04973, carbohydrate digestion and absorption	0.1251
			hsa04976, bile secretion	0.2678
	Cough suppressing and panting-calming	Clearing and heat phlegm resolving	hsa04978, mineral absorption	0.0380
			hsa04973, carbohydrate digestion and absorption	0.1572
			hsa04976, bile secretion	0.1958
	Tranquilizing	Heat nourishing tranquilizing	hsa04978, mineral absorption	0.0387
			hsa04973, carbohydrate digestion and absorption	0.1163
			hsa00900, terpenoid backbone biosynthesis	0.2166

Cluster VII	Heat-clearing medicinal	Heat-clearing and blood cooling	hsa04978, mineral absorption	0.0276
			hsa04973, carbohydrate digestion and absorption	0.0753
			hsa02010, ABC transporters	0.0769
	Hemostatic medicinal	Stasis resolving hemostatic	hsa04978, mineral absorption	0.0267
			hsa04973, carbohydrate digestion and absorption	0.0987
			hsa04976, bile secretion	0.1872
	Tonifying and replenishing	Blood tonifying	hsa04978, mineral absorption	0.0329
			hsa04973, carbohydrate digestion and absorption	0.1055
			hsa04530, tight junction	0.2053

Cluster XII	Parasite destroying, dampness eliminating, and itchiness relieving		hsa00100, steroid biosynthesis	0.253
			hsa00564, glycerophospholipid metabolism	0.294
			hsa04966, collecting duct acid secretion	0.342