Review Article

Efficacy and Safety of Chinese Medicinal Herbs for the Treatment of Hyperuricemia: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

Author, yearSample size (EG)Sample size (CG)Age (EG)Age (CG)Disease severity (EG)Disease severity (CG)Intervention method (/d) (EG)Intervention methods (/d) (CG)Duration treatment (d) (EG)Duration treatment (d) (CG)

Zhou, 2007 [13]363655.2 ± 6.153.8 ± 6.3SUA (umol/L): 518.2 ± 56.4SUA (umol/L): 518.6 ± 46.8Swordlike atractylodes (15 g), largehead atractylodes rhizome (15 g), Indian buead (15 g), plantain seed (10 g), etc.Allopurinol (0.1 g 3)2121
Chen, 2008 [14]383622~6522~65N/AN/AGlabrous greenbrier rhizome (45 g), seven-lobed yam rhizome (30 g), Carica papaya (15 g), plantain seed (15 g), etc.Allopurinol 0.2 g2828
Yu, 2012 [15]505048.12 ± 10.247.12 ± 11.5SUA (umol/L) (585.83 ± 93.93)SUA (umol/L) (584.94 ± 90.29)Glabrous greenbrier rhizome (50 g), herba lysimachiae (50 g), cortex phellodendri chinensis (15 g), swordlike atractylodes (15 g), etc.Allopurinol (0.1 g 2)3030
Tan et al., 2013 [16]303044.17 ± 8.2745.23 ± 9.35The course of disease: (8.54 ± 4.07) yearsThe course of disease: (8.10 ± 3.46) yearsGlabrous greenbrier rhizome (15 g), seven-lobed yam rhizome (20 g), jobstears seed (10 g), herba lysimachiae (15 g), etc.Allopurinol (0.1 g 3)5656
Li, 2007 [17]404055~8152~78N/AN/AJobstears seed (30 g), glabrous greenbrier rhizome (30 g), plantain deed (20 g), seven-lobed yam rhizome (20 g), etc.Allopurinol (0.1 g 3)6060
Xiang et al., 2014 [18]515145.62 ± 5.0544.72 ± 5.58The course of disease: (1.96 ± 0.45) yearsThe course of disease: (1.13 ± 0.46) yearsRadix clematidis (60 g), rhizoma polygonati odorati (20 g), radix achyranthis bidentatae (15 g)Allopurinol (0.05 g 3)9090
Cai et al., 2014 [19]505048 ± 1047 ± 12SUA (umol/L) (517.2 ± 86.33)SUA (umol/L) (514.5 ± 90.29)Cortex phellodendri chinensis (15 g), swordlike atractylodes (15 g), plantain seed (10 g), oriental waterplantain rhizome (10 g), etc.Allopurinol (0.1 g 3)2828
Zhou et al., 2010 [20]303035–7432–75N/AN/AGlabrous greenbrier rhizome (40 g), cortex phellodendri chinensis (15 g), swordlike atractylodes (15 g), jobstears seed (20 g), etc.Allopurinol (0.1 g 2)2828
Hong and Shen, 2011 [21]361851.8 ± 6.649.7 ± 5.1SUA (umol/L) (546.0 ± 78.1)SUA (umol/L) (533.0 ± 62.31)Glabrous greenbrier rhizome (15 g), cortex phellodendri chinensis (10 g), swordlike atractylodes (10 g), jobstears seed (30 g), etc.Allopurinol (0.1 g 3)6060
Hu, 2006 [22]404039.38 ± 10.8940.88 ± 11.13The course of disease: (2.64 ± 1.96) years, hypertension: 11, diabetes: 4, and hyperlipidaemia: 17The course of disease: (2.69 ± 1.86) years, hypertension: 14, diabetes: 1, and hyperlipidaemia: 15Glabrous greenbrier rhizome (30 g), jobstears seed (15 g), oriental waterplantain rhizome (15 g), herba lysimachiae (20 g), etc.Probenecid ()2828
Zhang et al., 2011 [23]282856.07 ± 17.6253.18 ± 16.40Hypertension: 9, diabetes: 7, hyperlipidaemia: 6, and coronary heart disease: 5Hypertension: 11, diabetes: 8, hyperlipidaemia: 7, and coronary heart disease: 5Glabrous greenbrier rhizome (35 g), seven-lobed yam rhizome (18 g), pseudobulb cremastra seu pleiones (15 g), radix achyranthis bidentatae (10 g), etc.Benzbromarone (50 mg 1)2020

EG: experimental group; CG: control group.
N/A: not applicable.
SUA: serum uric acid concentration.